ArticleJournal of neurodevelopmental disorders2011
DNA methylation, the early-life social environment and behavioral disorders.
Article in Journal of neurodevelopmental disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- An epigenome-wide association study meta-analysis of educational attainment.Molecular psychiatry · 2017Pooled it
- The Convergence of Early-Life Stress and Autism Spectrum Disorder on the Epigenetics of Genes Key to the HPA Axis.Biology · 2025Review
- DRDs and Brain-Derived Neurotrophic Factor Share a Common Therapeutic Ground: A Novel Bioinformatic Approach Sheds New Light Toward Pharmacological Treatment of Cognitive and Behavioral Disorders.Advances in experimental medicine and biology · 2023Article
- Genome-wide profiling of DNA methylome and transcriptome in peripheral blood monocytes for major depression: A Monozygotic Discordant Twin Study.Translational psychiatry · 2019Article
- Associations of monoamine oxidase A gene first exon methylation with sexual abuse and current depression in women.Journal of neural transmission (Vienna, Austria : 1996) · 2018Article
- DNA methylation patterns of behavior-related gene promoter regions dissect the gray wolf from domestic dog breeds.Molecular genetics and genomics : MGG · 2017Article
- Sex-Specific Effects of Prenatal Stress on Bdnf Expression in Response to an Acute Challenge in Rats: a Role for Gadd45β.Molecular neurobiology · 2016Article
- Early life adversity alters normal sex-dependent developmental dynamics of DNA methylation.Development and psychopathology · 2016Article
- The Role of Epigenetic Change in Autism Spectrum Disorders.Frontiers in neurology · 2015Review
- Serotonin 1B Receptor Gene (HTR1B) Methylation as a Risk Factor for Callous-Unemotional Traits in Antisocial Boys.PloS one · 2015Article
- Scrutinizing the epigenetics revolution.BioSocieties · 2014Article
- Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice.Neuropharmacology · 2013Article
- Have studies of the developmental regulation of behavioral phenotypes revealed the mechanisms of gene-environment interactions?Physiology & behavior · 2012Review
- Suicide among war veterans.International journal of environmental research and public health · 2012Review
- Tell me what you eat and I will tell you your sociotype: coping with diabesity.Rambam Maimonides medical journal · 2012Article
- Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the outstanding questions in behavioral disorders is untangling the complex relationship between nurture and nature. Although epidemiological data provide evidence that there is an interaction between genetics (nature) and the social and physical environments (nurture) in a spectrum of behavioral disorders, the main open question remains the mechanism. Emerging data support the hypothesis that DNA methylation, a covalent modification of the DNA molecule that is a component of its chemical structure, serves as an interface between the dynamic environment and the fixed genome. We propose that modulation of DNA methylation in response to environmental cues early in life serves as a mechanism of life-long genome adaptation. Under certain contexts, this adaptation can turn maladaptive resulting in behavioral disorders. This hypothesis has important implications on understanding, predicting, preventing, and treating behavioral disorders including autism that will be discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.