ArticleHepatology international2011
Evolution and management of de novo neoplasm post-liver transplantation: a 20-year experience from a single European centre.
Article in Hepatology international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Dynamic tumor-tracking stereotactic body radiation therapy for a solitary tumor in a transplanted organ: two case reports.International cancer conference journal · 2020Article
- Pretransplant Hepatic Malignancy Increases Risk of De Novo Malignancy after Liver Transplantation.Journal of Korean medical science · 2020Article
- Analysis of adult 20-year survivors after liver transplantation.Hepatology international · 2015Article
- De novo malignancy after liver transplantation: a single-center experience of 14 cases.Annals of surgical treatment and research · 2015Article
- De novo cancers following liver transplantation: a single center experience in China.PloS one · 2014Article
- Case report: Bone tumor of the scapula in a patient undergoing liver transplantation.Clinical orthopaedics and related research · 2012Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSurvival post-liver transplantation (LT) has improved; however, patients are considered at the, risk of malignancy due to prolonged immunosuppression. The long-term outcome of patients developing de novo neoplasm (DN) at our centre was evaluated.
methodsBetween October 1988 and December 2007, 800 LT were performed in 742 patients. Patients were divided into two study periods according to the time of LT; first: October 1988-December 1995; second: January 1996-December 2007.
resultsAfter a mean follow-up of 5 ± 4.6 years, 71 DN (9.5%) were detected in 742 patients. The cumulative risk of DN development increased with the time from LT although no differences at 3, 5, and 10 years were found when first and second periods were compared (3, 7, 16% vs. 2, 4, 11%, respectively; p = 0.4). DN incidence was higher in the first compared with the second period (10.7 vs. 7.8%; p < 0.04); no significant differences were observed in mortality rate (50 vs. 27%; p = 0.052). Actuarial patient survival post-DN at 1, 3, and 5 years: 67, 48, 45% versus 82, 71, 65%, in the first versus second period, respectively, p < 0.04.
conclusionsDN incidence has decreased in recent years; however, as survival post-LT increases, so does the incidence of DN. Surveillance programmes are necessary to diagnose DN at early stages.
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