ArticleLab on a chip2011
A cell-based biosensor for real-time detection of cardiotoxicity using lensfree imaging.
Article in Lab on a chip, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 94 citations in OpenAlex.
- Article
- Development of a high-speed imaging system for real time evaluation and monitoring of cardiac engineered tissues.Frontiers in bioengineering and biotechnology · 2024Article
- Multi-Illumination Single-Holographic-Exposure Lensless Fresnel (MISHELF) Microscopy: Principles and Biomedical Applications.Sensors (Basel, Switzerland) · 2023Review
- Modeling the human heart ex vivo-current possibilities and strive for future applications.Journal of tissue engineering and regenerative medicine · 2022Review
- Review
- Design, Calibration, and Application of a Robust, Cost-Effective, and High-Resolution Lensless Holographic Microscope.Sensors (Basel, Switzerland) · 2022Article
- Biomimetic design of bioartificial scaffolds for theFrontiers in bioengineering and biotechnology · 2022Article
- Novel Analysis Method for Beating Cells Videomicroscopy Data: Functional Characterization of Culture Samples.Frontiers in physiology · 2022Article
- High-Throughput Methods in the Discovery and Study of Biomaterials and Materiobiology.Chemical reviews · 2021Review
- Muscular Thin Films for Label-Free Mapping of Excitation Propagation in Cardiac Tissue.Annals of biomedical engineering · 2020Article
- A miniaturized optical tomography platform for volumetric imaging of engineered living systems.Lab on a chip · 2019Article
- Reflective lens-free imaging on high-density silicon microelectrode arrays for monitoring and evaluation ofBiomedical optics express · 2018Article
- MBiosensors & bioelectronics · 2018Article
- Engineered 3D Cardiac Fibrotic Tissue to Study Fibrotic Remodeling.Advanced healthcare materials · 2017Article
- Three-Dimensional Cell Cultures in Drug Discovery and Development.SLAS discovery : advancing life sciences R & D · 2017Review
- Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip.Biomaterials · 2016Article
- Aptamer-Based Microfluidic Electrochemical Biosensor for Monitoring Cell-Secreted Trace Cardiac Biomarkers.Analytical chemistry · 2016Article
- Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling.Drug discovery today · 2016Review
- Hybrid Microscopy: Enabling Inexpensive High-Performance Imaging through Combined Physical and Optical Magnifications.Scientific reports · 2016Article
- Google Glass-Directed Monitoring and Control of Microfluidic Biosensors and Actuators.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
A portable and cost-effective real-time cardiotoxicity biosensor was developed using a CMOS imaging module extracted from a commercially available webcam. The detection system consists of a CMOS imaging module, a white LED and a pinhole. Real-time image processing was conducted by comparing reference and live frame images. To evaluate the engineered system, the effects of two different drugs, isoprenaline and doxorubicin, on the beating rate and beat-to-beat variations of ESC-derived cardiomyocytes were measured. The detection system was used to conclude that the beat-to-beat variability increased under treatment with both isoprenaline and doxorubicin. However, the beating rates increased upon the addition of isoprenaline but decreased for cultures supplemented with doxorubicin. Moreover, the response time for both the beating rates and the beat-to-beat variability of ESC-derived cardiomyocytes under treatment of isoprenaline was shorter than for doxorubicin, although the amount of isoprenaline used in the measurement was three orders of magnitude lower than that of doxorubicin. Given its ability to perform real-time cell monitoring in a simple and inexpensive manner, the proposed system may be useful for a range of cell-based biosensing applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.