ArticlePloS one2011
Mechanical properties of organelles driven by microtubule-dependent molecular motors in living cells.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Simulations suggest robust microtubule attachment of kinesin and dynein in antagonistic pairs.Biophysical journal · 2023Article
- Mechanism of elastic energy storage of honey bee abdominal muscles under stress relaxation.Journal of insect science (Online) · 2023Article
- Investigation of multiple-dynein transport of melanosomes by non-invasive force measurement using fluctuation unit χ.Scientific reports · 2019Article
- Thermodynamic Efficiency of Somatic Exocytosis of Serotonin.Frontiers in physiology · 2019Article
- Assessing the Impact of Electrostatic Drag on Processive Molecular Motor Transport.Bulletin of mathematical biology · 2018Article
- Retraction of rod-like mitochondria during microtubule-dependent transport.Bioscience reports · 2018Article
- Probing Mitotic CENP-E Kinesin with the Tethered Cargo Motion Assay and Laser Tweezers.Biophysical journal · 2018Article
- Sensing Magnetic Fields with Magnetosensitive Ion Channels.Sensors (Basel, Switzerland) · 2018Article
- Mechanical coupling of microtubule-dependent motor teams during peroxisome transport in Drosophila S2 cells.Biochimica et biophysica acta. General subjects · 2017Article
- Dividing organelle tracks into Brownian and motor-driven intervals by variational maximization of the Bayesian evidence.European biophysics journal : EBJ · 2016Article
- Molecular machines operating on the nanoscale: from classical to quantum.Beilstein journal of nanotechnology · 2016Review
- Nanoparticle-assisted optical tethering of endosomes reveals the cooperative function of dyneins in retrograde axonal transport.Scientific reports · 2015Article
- Retrograde NGF axonal transport--motor coordination in the unidirectional motility regime.Biophysical journal · 2015Article
- How molecular motors work in the crowded environment of living cells: coexistence and efficiency of normal and anomalous transport.PloS one · 2014Article
- Centromere tethering confines chromosome domains.Molecular cell · 2013Article
- Intrinsic Disorder in the Kinesin Superfamily.Biophysical reviews · 2013Article
- Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.Open biology · 2013Article
- Article
- Expanding horizons: ciliary proteins reach beyond cilia.Annual review of genetics · 2013Review
- Overexpression of Kinesin Associated Protein 3 (KIFAP3) in Breast Cancer.Journal of proteomics & bioinformatics · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The organization of the cytoplasm is regulated by molecular motors which transport organelles and other cargoes along cytoskeleton tracks. Melanophores have pigment organelles or melanosomes that move along microtubules toward their minus and plus end by the action of cytoplasmic dynein and kinesin-2, respectively. In this work, we used single particle tracking to characterize the mechanical properties of motor-driven organelles during transport along microtubules. We tracked organelles with high temporal and spatial resolutions and characterized their dynamics perpendicular to the cytoskeleton track. The quantitative analysis of these data showed that the dynamics is due to a spring-like interaction between melanosomes and microtubules in a viscoelastic microenvironment. A model based on a generalized Langevin equation explained these observations and predicted that the stiffness measured for the motor complex acting as a linker between organelles and microtubules is ∼ one order smaller than that determined for motor proteins in vitro. This result suggests that other biomolecules involved in the interaction between motors and organelles contribute to the mechanical properties of the motor complex. We hypothesise that the high flexibility observed for the motor linker may be required to improve the efficiency of the transport driven by multiple copies of motor molecules.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.