ArticlePLoS genetics2011
Systematic detection of polygenic cis-regulatory evolution.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Predicting Gene Expression Responses to Cold inGenes · 2025Article
- Single-cell chromatin accessibility profiling reveals regulatory mechanisms and evolution in pig brains.BMC biology · 2025Article
- Gene-by-environment Interactions and Adaptive Body Size Variation in Mice From the Americas.Molecular biology and evolution · 2025Article
- Fixation of Expression Divergences by Natural Selection inInternational journal of molecular sciences · 2024Article
- Stem cell transcriptional profiles from mouse subspecies reveal cis-regulatory evolution at translation genes.Heredity · 2024Article
- Extensive transcriptome data providing great efficacy in genetic research and adaptive gene discovery: a case study ofFrontiers in plant science · 2024Article
- Environmentally robustProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Evolution of Spatial and Temporal cis-Regulatory Divergence in Sticklebacks.Molecular biology and evolution · 2023Article
- Existing methods are effective at measuring natural selection on gene expression.Nature ecology & evolution · 2022Article
- Reply to: Existing methods are effective at measuring natural selection on gene expression.Nature ecology & evolution · 2022Article
- Distinct signals of clinal and seasonal allele frequency change at eQTLs in Drosophila melanogaster.Evolution; international journal of organic evolution · 2022Article
- Article
- Ghost QTL and hotspots in experimental crosses: novel approach for modeling polygenic effects.Genetics · 2021Article
- The long-term restoration of ecosystem complexity.Nature ecology & evolution · 2020Review
- Behavior-dependentProceedings of the National Academy of Sciences of the United States of America · 2018Article
- The Evolution of Gene Expression in cis and trans.Trends in genetics : TIG · 2018Review
- Coordinated Functional Divergence of Genes after Genome Duplication inThe Plant cell · 2017Article
- High rate of adaptation of mammalian proteins that interact with Plasmodium and related parasites.PLoS genetics · 2017Article
- Cis-regulatory evolution in prokaryotes revealed by interspecific archaeal hybrids.Scientific reports · 2017Article
- Genomic evidence for local adaptation in the ovoviviparous marine fish Sebastiscus marmoratus with a background of population homogeneity.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The idea that most morphological adaptations can be attributed to changes in the cis-regulation of gene expression levels has been gaining increasing acceptance, despite the fact that only a handful of such cases have so far been demonstrated. Moreover, because each of these cases involves only one gene, we lack any understanding of how natural selection may act on cis-regulation across entire pathways or networks. Here we apply a genome-wide test for selection on cis-regulation to two subspecies of the mouse Mus musculus. We find evidence for lineage-specific selection at over 100 genes involved in diverse processes such as growth, locomotion, and memory. These gene sets implicate candidate genes that are supported by both quantitative trait loci and a validated causality-testing framework, and they predict a number of phenotypic differences, which we confirm in all four cases tested. Our results suggest that gene expression adaptation is widespread and that these adaptations can be highly polygenic, involving cis-regulatory changes at numerous functionally related genes. These coordinated adaptations may contribute to divergence in a wide range of morphological, physiological, and behavioral phenotypes.
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