ArticleFrontiers in neuroanatomy2011
The evolution of dopamine systems in chordates.
Article in Frontiers in neuroanatomy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
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Who cites it
88 citing papers in PubMed, 230 citations in OpenAlex.
- Characterization of Dopamine Receptors in Sepia officinalis (Cephalopoda): An Insight Into the Evolution of Dopamine Receptors in Bilateria.Marine biotechnology (New York, N.Y.) · 2026Article
- Characterization of Fish Serotonin, Dopamine and Norepinephrine Transporters as a Potential Target for Environmental Pharmaceuticals.Environmental science & technology · 2026Article
- Genomic Patterns of Parallel Divergence Across Demographically Heterogeneous Stickleback Populations in Eastern Canada.Genome biology and evolution · 2026Article
- Differences in the Effect of Dopamine on the Phototransduction Between Lampreys and Jawed Vertebrates.International journal of molecular sciences · 2026Article
- Article
- An LC-MS/MS-based approach for monitoring monoaminergic status in lizard brains: method development and real-samples application.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025Article
- Dopaminergic Neurons in the Zebrafish Subpallium Belong to the Extended Medial Amygdala.The Journal of comparative neurology · 2025Article
- Food reward entrainment increases mealtime anxiety in goldfish via a ghrelin-dependent mechanism.Scientific reports · 2025Article
- Molecular characterization of chicken DA systems reveals that the avian personality gene,Frontiers in neuroanatomy · 2025Article
- Drosophila as an Animal Model To Determine the Functional and Behavioral Significance of Dopamine Transporter Genetic Variations Associated with Brain Disorders.Advances in neurobiology · 2025Review
- From emotional arousal to executive action. Role of the prefrontal cortex.Brain structure & function · 2024Review
- The Drosophila dopamine 2-like receptor D2R (Dop2R) is required in the blood brain barrier for male courtship.Genes, brain, and behavior · 2023Article
- Lasting mesothalamic dopamine imbalance and altered exploratory behavior in rats after a mild neonatal hypoxic event.Frontiers in integrative neuroscience · 2023Article
- CRISPR/Cas9-based QF2 knock-in at theFrontiers in neuroanatomy · 2023Article
- Molecular biology of serotonergic systems in avian brains.Frontiers in molecular neuroscience · 2023Review
- Temperature- and chemical-induced neurotoxicity in zebrafish.Frontiers in physiology · 2023Review
- Peripheral NOD-like receptor deficient inflammatory macrophages trigger neutrophil infiltration into the brain disrupting daytime locomotion.Communications biology · 2022Article
- Serotonin receptors contribute to dopamine depression of lateral inhibition in the nucleus accumbens.Cell reports · 2022Article
- Somatic regulation of female germ cell regeneration and development in planarians.Cell reports · 2022Article
- Allosteric Modulator KM822 Attenuates Behavioral Actions of Amphetamine inMolecular pharmacology · 2022Article
28 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dopamine (DA) neurotransmission in the central nervous system (CNS) is found throughout chordates, and its emergence predates the divergence of chordates. Many of the molecular components of DA systems, such as biosynthetic enzymes, transporters, and receptors, are shared with those of other monoamine systems, suggesting the common origin of these systems. In the mammalian CNS, the DA neurotransmitter systems are diversified and serve for visual and olfactory perception, sensory-motor programming, motivation, memory, emotion, and endocrine regulations. Some of the functions are conserved among different vertebrate groups, while others are not, and this is reflected in the anatomical aspects of DA systems in the forebrain and midbrain. Recent findings concerning a second tyrosine hydroxylase gene (TH2) revealed new populations of DA-synthesizing cells, as evidenced in the periventricular hypothalamic zones of teleost fish. It is likely that the ancestor of vertebrates possessed TH2 DA-synthesizing cells, and the TH2 gene has been lost secondarily in placental mammals. All the vertebrates possess DA cells in the olfactory bulb, retina, and in the diencephalon. Midbrain DA cells are abundant in amniotes while absent in some groups, e.g., teleosts. Studies of protochordate DA cells suggest that the diencephalic DA cells were present before the divergence of the chordate lineage. In contrast, the midbrain cell populations have probably emerged in the vertebrate lineage following the development of the midbrain-hindbrain boundary. The functional flexibility of the DA systems, and the evolvability provided by duplication of the corresponding genes permitted a large diversification of these systems. These features were instrumental in the adaptation of brain functions to the very variable way of life of vertebrates.
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