ArticlePloS one2011
Saccharomyces cerevisiae modulates immune gene expressions and inhibits ETEC-mediated ERK1/2 and p38 signaling pathways in intestinal epithelial cells.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 131 citations in OpenAlex.
- Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics.World journal of gastroenterology · 2014Pooled it
- Trial
- Cross-kingdom microbial interactions in the gut during inflammatory bowel disease.Journal of translational medicine · 2026Review
- Ningxiang pig-derived Lactobacillus reuteri improves the gut health of weaned piglets by regulating intestinal barrier function and cytokine profiles.Scientific reports · 2025Article
- Combined supplementation of essential oils, Saccharomyces cerevisiae and isomaltooligosaccharides improves intestinal absorption and immune functions in weaned piglets.Journal of animal science · 2025Article
- Establishment of an in vitro evaluation method for immunomodulatory functions of yeast strains.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024Article
- Medium- and Long-Term Immune Responses in the Small Intestine in Piglets from Oral Vaccination againstAnimals : an open access journal from MDPI · 2024Article
- Investigation of the impact of multi-strain probiotics containingJournal of animal science and technology · 2024Review
- A Narrative Review on the Advance of Probiotics to Metabiotics.Journal of microbiology and biotechnology · 2024Review
- Effects of yeast culture on growth performance, immune function, antioxidant capacity and hormonal profile in Mongolian ram lambs.Frontiers in veterinary science · 2024Article
- Core-predominant gut fungus Kazachstania slooffiae promotes intestinal epithelial glycolysis via lysine desuccinylation in pigs.Microbiome · 2023Article
- Looking for Possible Benefits of Combining Short-Chain Fructo-Oligosaccharides (scFOS) withAnimals : an open access journal from MDPI · 2023Article
- Yeast Culture Supplementation Effects on Systemic and Polymorphonuclear Leukocytes' mRNA Biomarkers of Inflammation and Liver Function in Peripartal Dairy Cows.Animals : an open access journal from MDPI · 2023Article
- METTL3 Regulates the Inflammatory Response in CPB2 Toxin-Exposed IPEC-J2 Cells through the TLR2/NF-κB Signaling Pathway.International journal of molecular sciences · 2022Article
- Article
- Effects of Five Filamentous Fungi Used in Food Processes on In Vitro and In Vivo Gut Inflammation.Journal of fungi (Basel, Switzerland) · 2022Article
- Intestinal and Mucosal Microbiome Response to Oral Challenge of EnterotoxigenicPathogens (Basel, Switzerland) · 2022Article
- Bacteriophage EK99P-1 alleviates enterotoxigenic Escherichia coli K99-induced barrier dysfunction and inflammation.Scientific reports · 2022Article
- Article
- Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease.Nature medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEnterotoxigenic Escherichia coli (ETEC) infections result in large economic losses in the swine industry worldwide. ETEC infections cause pro-inflammatory responses in intestinal epithelial cells and subsequent diarrhea in pigs, leading to reduced growth rate and mortality. Administration of probiotics as feed additives displayed health benefits against intestinal infections. Saccharomyces cerevisiae (Sc) is non-commensal and non-pathogenic yeast used as probiotic in gastrointestinal diseases. However, the immuno-modulatory effects of Sc in differentiated porcine intestinal epithelial cells exposed to ETEC were not investigated. METHODOLOGY/PRINCIPAL
findingsWe reported that the yeast Sc (strain CNCM I-3856) modulates transcript and protein expressions involved in inflammation, recruitment and activation of immune cells in differentiated porcine intestinal epithelial IPEC-1 cells. We demonstrated that viable Sc inhibits the ETEC-induced expression of pro-inflammatory transcripts (IL-6, IL-8, CCL20, CXCL2, CXCL10) and proteins (IL-6, IL-8). This inhibition was associated to a decrease of ERK1/2 and p38 MAPK phosphorylation, an agglutination of ETEC by Sc and an increase of the anti-inflammatory PPAR-γ nuclear receptor mRNA level. In addition, Sc up-regulates the mRNA levels of both IL-12p35 and CCL25. However, measurement of transepithelial electrical resistance displayed that Sc failed to maintain the barrier integrity in monolayer exposed to ETEC suggesting that Sc does not inhibit ETEC enterotoxin activity.
conclusionsSc (strain CNCM I-3856) displays multiple immuno-modulatory effects at the molecular level in IPEC-1 cells suggesting that Sc may influence intestinal inflammatory reaction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.