ArticleWorld journal of gastroenterology2011
Discovery and validation of prognostic markers in gastric cancer by genome-wide expression profiling.
Article in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 54 citations in OpenAlex.
- A Comprehensive Review on the Importance of MiRNA-206 in the Animal Model and Human Diseases.Current neuropharmacology · 2024Review
- Circular RNA 0001789 sponges miR-140-3p and regulates PAK2 to promote the progression of gastric cancer.Journal of translational medicine · 2023Article
- Oncogenic role of LYN in human gastric cancer via the Wnt/β-catenin and AKT/mTOR pathways.Experimental and therapeutic medicine · 2020Article
- Evaluation of predictive role of carcinoembryonic antigen and salivary mRNA biomarkers in gastric cancer detection.Medicine · 2020Article
- CDK12 and PAK2 as novel therapeutic targets for human gastric cancer.Theranostics · 2020Article
- Identification of key regulators in prostate cancer from gene expression datasets of patients.Scientific reports · 2019Article
- Immunohistochemical classification of gastric cancer based on new molecular biomarkers: a potential predictor of survival.Virchows Archiv : an international journal of pathology · 2018Article
- MicroRNA-139 inhibits the proliferation, migration and invasion of gastric cancer cells by directly targeting ρ-associated protein kinase 1.Oncology letters · 2018Article
- Integrative machine learning analysis of multiple gene expression profiles in cervical cancer.PeerJ · 2018Article
- How does epidemiological and clinicopathological features affect survival after gastrectomy for gastric cancer patients-single Egyptian center experience.World journal of gastrointestinal surgery · 2016Article
- PSMB8 and PBK as potential gastric cancer subtype-specific biomarkers associated with prognosis.Oncotarget · 2016Article
- Prognostic value of microRNA-126 and CRK expression in gastric cancer.OncoTargets and therapy · 2016Article
- Expression and significance of annexin A2 in patients with gastric adenocarcinoma and the association with E-cadherin.Experimental and therapeutic medicine · 2015Article
- Transferring genomics to the clinic: distinguishing Burkitt and diffuse large B cell lymphomas.Genome medicine · 2015Article
- Molecular classification and prediction in gastric cancer.Computational and structural biotechnology journal · 2015Review
- Prognostic significance of the co-expression of nucleophosmin and trefoil factor 3 in postoperative gastric cancer patients.Molecular and clinical oncology · 2014Article
- Activation of P21-activated protein kinase 2 is an independent prognostic predictor for patients with gastric cancer.Diagnostic pathology · 2014Article
- Expression characteristics of CDC20 in gastric cancer and its correlation with poor prognosis.International journal of clinical and experimental pathology · 2014Article
- Reduced expression of miR-22 in gastric cancer is related to clinicopathologic characteristics or patient prognosis.Diagnostic pathology · 2013Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo develop a prognostic gene set that can predict patient overall survival status based on the whole genome expression analysis.
methodsUsing Illumina HumanWG-6 BeadChip followed by semi-supervised analysis, we analyzed the expression of 47,296 transcripts in two batches of gastric cancer patients who underwent surgical resection. Thirty-nine samples in the first batch were used as the training set to discover candidate markers correlated to overall survival, and thirty-three samples in the second batch were used for validation.
resultsA panel of ten genes were identified as prognostic marker in the first batch samples and classified patients into a low- and a high-risk group with significantly different survival times (P = 0.000047). This prognostic marker was then verified in an independent validation sample batch (P = 0.0009). By comparing with the traditional Tumor-node-metastasis (TNM) staging system, this ten-gene prognostic marker showed consistent prognosis results. It was the only independent prognostic value by multivariate Cox regression analysis (P = 0.007). Interestingly, six of these ten genes are ribosomal proteins, suggesting a possible association between the deregulation of ribosome related gene expression and the poor prognosis.
conclusionA ten-gene marker correlated with overall prognosis, including 6 ribosomal proteins, was identified and verified, which may complement the predictive value of TNM staging system.
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