ArticleThe Libyan journal of medicine2010
Genotoxic effect induced by hydrogen peroxide in human hepatoma cells using comet assay.
Article in The Libyan journal of medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- AcuteBiology · 2026Article
- Agent-specific DNA repair kinetic in 3T3 cells: a comparative study using the in vitro comet assay.Toxicology research · 2025Article
- Rapid detection of hydrogen peroxide and nitrite in adulterated cow milk using enzymatic and nonenzymatic methods on a reusable platform.RSC advances · 2025Article
- Comprehensive antigenotoxic profile of endemicFood science and biotechnology · 2024Article
- Article
- Preliminary Insights into the Antigenotoxic Potential of Lemon Essential Oil and Olive Oil in Human Peripheral Blood Mononuclear Cells.Plants (Basel, Switzerland) · 2024Article
- Isolation of a novel quercetin derivative fromResearch in pharmaceutical sciences · 2024Article
- Synthesis, Crystal Structures, Genotoxicity, and Antifungal and Antibacterial Studies of Ni(II) and Cd(II) Pyrazole Amide Coordination Complexes.Molecules (Basel, Switzerland) · 2024Article
- Modes of Action of a Novel c-MYC Inhibiting 1,2,4-Oxadiazole Derivative in Leukemia and Breast Cancer Cells.Molecules (Basel, Switzerland) · 2023Article
- Synergistic Effects of Sanglifehrin-Based Cyclophilin Inhibitor NV651 with Cisplatin in Hepatocellular Carcinoma.Cancers · 2022Article
- Cell survival after DNA damage in the comet assay.Archives of toxicology · 2021Article
- Genotoxicity of Water Extract from Bark-RemovedMolecules (Basel, Switzerland) · 2021Article
- Article
- Molecular and cellular responses to short exposure to bisphenols A, F, and S and eluates of microplastics in C. elegans.Environmental science and pollution research international · 2021Article
- The Effects of Thymoquinone on Viability, and Anti-apoptotic Factors (BCL-XL, BCL-2, MCL-1) in Prostate Cancer (PC3) Cells: An In Vitro and Computer-Simulated Environment Study.Advanced pharmaceutical bulletin · 2019Article
- Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma.Antioxidants (Basel, Switzerland) · 2019Article
- Antigenotoxic Effects of Biochaga and Dihydroquercetin (Taxifolin) on HOxidative medicine and cellular longevity · 2019Article
- The Study of Apoptosis-inducing Effects of Three Pre-apoptotic Factors by Gallic Acid, Using Simulation Analysis and the Comet Assay Technique on the Prostatic Cancer Cell Line PC3.The Malaysian journal of medical sciences : MJMS · 2017Article
- Antigenotoxic Properties ofOxidative medicine and cellular longevity · 2017Article
- Cytogenetic and oxidative alterations after exposure of cultured human whole blood cells to lithium metaborate dehydrate.Cytotechnology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHydrogen peroxide (H(2)O(2)) is a common reactive oxygen intermediate generated by various forms of oxidative stress.
aimThe aim of this study was to investigate the DNA damage capacity of H(2)O(2) in HepG2 cells.
methodsCells were treated with H(2)O(2) at concentrations of 25 µM or 50 µM for 5 min, 30 min, 40 min, 1 h, or 24 h in parallel. The extent of DNA damage was assessed by the comet assay.
resultsCompared to the control, DNA damage by 25 and 50 µM H(2)O(2) increased significantly with increasing incubation time up to 1 h, but it was not increased at 24 h.
conclusionsOur findings confirm that H(2)O(2) is a typical DNA damage-inducing agent and thus is a good model system to study the effects of oxidative stress. DNA damage in HepG2 cells increased significantly with H(2)O(2) concentration and time of incubation but later decreased likely due to DNA repair mechanisms and antioxidant enzymes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.