ArticlePLoS computational biology2011
The roots of bioinformatics in theoretical biology.
Article in PLoS computational biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed.
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- Expanding bioinformatics: Toward a paradigm shift from data to theory.Fundamental research · 2026Review
- Expression of stearoyl coenzyme a desaturase in neuronal cells facilitates pancreatic cancer progression.Cancer cell international · 2025Article
- A bioinformatician, computer scientist, and geneticist lead bioinformatic tool development-which one is better?Bioinformatics advances · 2025Article
- Identification of effective diagnostic genes and immune cell infiltration characteristics in small cell lung cancer by integrating bioinformatics analysis and machine learning algorithms.Saudi medical journal · 2024Article
- Structural Landscape of nsp Coding Genomic Regions of SARS-CoV-2-ssRNA Genome: A Structural Genomics Approach Toward Identification of Druggable Genome, Ligand-Binding Pockets, and Structure-Based Druggability.Molecular biotechnology · 2024Article
- Identification of differentially expressed genes, pathways, and immune infiltration in diabetes.Clinics (Sao Paulo, Brazil) · 2024Article
- A Historic Retrospective on the Early Bioinformatics Research in China.Genomics, proteomics & bioinformatics · 2023Article
- Invited Expert Opinion- Bioinformatic and Limitation Directives to Help Adopt Genetic Addiction Risk Screening and Identify Preaddictive Reward Dysregulation: Required Analytic Evidence to Induce Dopamine Homeostatsis.Medical research archives · 2023Article
- Self-Organization and Genomic Causality in Models of Morphogenesis.Entropy (Basel, Switzerland) · 2023Review
- Interpreting T-cell search "strategies" in the light of evolution under constraints.PLoS computational biology · 2023Article
- Editorial: Vetinformatics: an insight for decoding livestock systems throughFrontiers in veterinary science · 2023Article
- CompositeView: A Network-Based Visualization Tool.Big data and cognitive computing · 2022Article
- Computational characterization and analysis of molecular sequence data of Elizabethkingia meningoseptica.BMC research notes · 2022Article
- Theranostic Interpolation of Genomic Instability in Breast Cancer.International journal of molecular sciences · 2022Review
- A Bibliometric Analysis of Mexican Bioinformatics: A Portrait of Actors, Structure, and Dynamics.Biology · 2022Article
- Vetinformatics from functional genomics to drug discovery: Insights into decoding complex molecular mechanisms of livestock systems in veterinary science.Frontiers in veterinary science · 2022Review
- In vivo, in vitro and in silico: an open space for the development of microbe-based applications of synthetic biology.Microbial biotechnology · 2022Article
- MicroRNA and Hemophilia-A Disease: Bioinformatics Prediction and Experimental Analysis.Cell journal · 2021Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
From the late 1980s onward, the term "bioinformatics" mostly has been used to refer to computational methods for comparative analysis of genome data. However, the term was originally more widely defined as the study of informatic processes in biotic systems. In this essay, I will trace this early history (from a personal point of view) and I will argue that the original meaning of the term is re-emerging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.