ArticleAging2011
Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster.
Article in Aging, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- CREB suppresses PGRP-SC2 to drive age-related immune senescence and gut dysbiosis in Drosophila.Cell death discovery · 2026Article
- Chemical modulation of IMD signaling in the cat flea (Current research in insect science · 2026Article
- Distribution Analysis of the Lifespan Trait in Drosophila.International journal of molecular sciences · 2025Article
- Human Umbilical Cord Mesenchymal-Stem-Cell-Derived Extracellular Vesicles Reduce Skin Inflammation In Vitro.International journal of molecular sciences · 2023Article
- Review
- Biological mechanisms of aging predict age-related disease co-occurrence in patients.Aging cell · 2022Article
- Systems approaches to investigate the role of NF-κB signaling in aging.The Biochemical journal · 2022Review
- Role of NF-κB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse Models.Cells · 2021Review
- Functional conservation in genes and pathways linking ageing and immunity.Immunity & ageing : I & A · 2021Review
- Social modulation of ageing: mechanisms, ecology, evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Drug Screening Implicates Chondroitin Sulfate as a Potential Longevity Pill.Frontiers in aging · 2021Review
- Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience.Aging and disease · 2020Article
- Amyloid-β peptides slightly affect lifespan or antimicrobial peptide gene expression in Drosophila melanogaster.BMC genetics · 2020Article
- A universal transcriptomic signature of age reveals the temporal scaling of Caenorhabditis elegans aging trajectories.Scientific reports · 2019Article
- Article
- Overexpression of antimicrobial peptides contributes to aging through cytotoxic effects in Drosophila tissues.Archives of insect biochemistry and physiology · 2018Article
- Current Perspective in the Discovery of Anti-aging Agents from Natural Products.Natural products and bioprospecting · 2017Review
- Geroprotectors: A Unified Concept and Screening Approaches.Aging and disease · 2017Review
- NF-κB Immunity in the Brain Determines Fly Lifespan in Healthy Aging and Age-Related Neurodegeneration.Cell reports · 2017Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is associated with NF-κB-dependent pro-inflammation. Here we demonstrated that inhibition of NF-κB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.