ArticleProceedings of the National Academy of Sciences of the United States of America2011
Genomic RNAs of Borna disease virus are elongated on internal template motifs after realignment of the 3' termini.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Structure and function of the RNA polymerase complex of Borna disease virus, a nuclear-replicating non-segmented negative-strand RNA virus.Nucleic acids research · 2026Article
- The structure of the mammalian bornavirus polymerase complex.Nature communications · 2025Article
- Borna disease virus 2 maintains genomic polymorphisms by superinfection in persistently infected cells.Npj viruses · 2025Article
- Reverse genetics of parrot bornavirus 4 reveals a unique splicing of the glycoprotein gene that affects viral propagation.Journal of virology · 2023Article
- Analysis of Template Variations on RNA Synthesis by Respiratory Syncytial Virus Polymerase.Viruses · 2022Article
- Comparison of RNA synthesis initiation properties of non-segmented negative strand RNA virus polymerases.PLoS pathogens · 2021Article
- ADAR2 Is Involved in Self and Nonself Recognition of Borna Disease Virus Genomic RNA in the Nucleus.Journal of virology · 2020Article
- Ebolavirus polymerase uses an unconventional genome replication mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- A Mechanism for Priming and Realignment during Influenza A Virus Replication.Journal of virology · 2018Article
- piRNAs derived from ancient viral processed pseudogenes as transgenerational sequence-specific immune memory in mammals.RNA (New York, N.Y.) · 2015Article
- Review
- Borna disease virus possesses an NF-ĸB inhibitory sequence in the nucleoprotein gene.Scientific reports · 2015Article
- Absence of a robust innate immune response in rat neurons facilitates persistent infection of Borna disease virus in neuronal tissue.Cellular and molecular life sciences : CMLS · 2013Article
- A structure-based model of RIG-I activation.RNA (New York, N.Y.) · 2012Review
- Tick-borne Nyamanini virus replicates in the nucleus and exhibits unusual genome and matrix protein properties.Journal of virology · 2012Article
- The respiratory syncytial virus polymerase has multiple RNA synthesis activities at the promoter.PLoS pathogens · 2012Article
- A novel borna disease virus vector system that stably expresses foreign proteins from an intercistronic noncoding region.Journal of virology · 2011Article
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5 authors.
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Abstract
The terminal structures of the Borna disease virus (BDV) genome (vRNA) and antigenome (cRNA) differ from those of other negative strand RNA viruses, as both molecules possess four nucleotides at the 3' terminus without an apparent template at the 5' end of the opposite strand. Consequently, the v- and cRNA molecules are not perfect mirror images, a situation that is not compatible with conventional strategies to maintain genetic information. We show here that recombinant viruses recovered from cDNA lacking the nontemplated nucleotides efficiently reconstitute the 3' overhangs. Analyses of recombinant viruses encoding genetic markers in potential alternative template sequences demonstrated that the BDV v- and cRNA molecules are extended by a realign-and-elongation process on internal template motifs located in close proximity to the 3' ends of v- and cRNA, respectively. The data further suggest that cRNA elongation is restricted to a single template motif of the nascent strand, whereas elongation of vRNA might use multiple template motifs. We propose that the elongation of the 3' termini supports the terminal integrity of the genomic RNA molecules during BDV persistence, and furthermore provides an elegant strategy to eliminate the triphosphate groups from the 5' termini of the BDV v- and cRNA without compromising the genetic information of the virus.
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