ArticleMolecular and cellular biology2011
Mediator influences telomeric silencing and cellular life span.
Article in Molecular and cellular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Immunoinflammation and post-translational modifications in the aging process.Journal of translational medicine · 2025Review
- Review
- Global histone protein surface accessibility in yeast indicates a uniformly loosely packed genome with canonical nucleosomes.Epigenetics & chromatin · 2021Article
- A role for MED14 and UVH6 in heterochromatin transcription upon destabilization of silencing.Life science alliance · 2018Article
- Toward understanding of the mechanisms of Mediator function in vivo: Focus on the preinitiation complex assembly.Transcription · 2017Review
- Fungal KATs/KDACs: A New Highway to Better Antifungal Drugs?PLoS pathogens · 2016Review
- The Mediator complex: a central integrator of transcription.Nature reviews. Molecular cell biology · 2015Review
- A functional portrait of Med7 and the mediator complex in Candida albicans.PLoS genetics · 2014Article
- Pivotal role for a tail subunit of the RNA polymerase II mediator complex CgMed2 in azole tolerance and adherence in Candida glabrata.Antimicrobial agents and chemotherapy · 2014Article
- Yeast sirtuins and the regulation of aging.FEMS yeast research · 2014Review
- Mediator links transcription and DNA repair by facilitating Rad2/XPG recruitment.Genes & development · 2013Article
- Differential regulation of white-opaque switching by individual subunits of Candida albicans mediator.Eukaryotic cell · 2013Article
- The Tlo proteins are stoichiometric components of Candida albicans mediator anchored via the Med3 subunit.Eukaryotic cell · 2012Article
- Role of Mediator in regulating Pol II elongation and nucleosome displacement in Saccharomyces cerevisiae.Genetics · 2012Article
- The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance.Nucleic acids research · 2012Article
- Genome-wide profiling of pluripotent cells reveals a unique molecular signature of human embryonic germ cells.PloS one · 2012Article
- Med5(Nut1) and Med17(Srb4) are direct targets of mediator histone H4 tail interactions.PloS one · 2012Article
- The functions of Mediator in Candida albicans support a role in shaping species-specific gene expression.PLoS genetics · 2012Article
- Genetic and physical interactions between Tel2 and the Med15 Mediator subunit in Saccharomyces cerevisiae.PloS one · 2012Article
- Histone modifications influence mediator interactions with chromatin.Nucleic acids research · 2011Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 4 countries.
Funding
Abstract
The Mediator complex is required for the regulated transcription of nearly all RNA polymerase II-dependent genes. Here we demonstrate a new role for Mediator which appears to be separate from its function as a transcriptional coactivator. Mediator associates directly with heterochromatin at telomeres and influences the exact boundary between active and inactive chromatin. Loss of the Mediator Med5 subunit or mutations in Med7 cause a depletion of the complex from regions located near subtelomeric X elements, which leads to a change in the balance between the Sir2 and Sas2 proteins. These changes in turn result in increased levels of H4K16 acetylation near telomeres and in desilencing of subtelomeric genes. Increases in H4K16 acetylation have been observed at telomeres in aging cells. In agreement with this observation, we found that the loss of MED5 leads to shortening of the Saccharomyces cerevisiae (budding yeast) replicative life span.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.