Evidence map›Paper›PMID 21482635›Full record

Trial reportEndocrine-related cancer2011

Changes in insulin resistance indicators, IGFs, and adipokines in a year-long trial of aerobic exercise in postmenopausal women.

Christine M Friedenreich, Heather K Neilson, Christy G Woolcott, Anne McTiernan, Qinggang Wang, Rachel Ballard-Barbash, Charlotte A Jones, Frank Z Stanczyk, Rollin F Brant, Yutaka Yasui and 5 more

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Endocrine-related cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 7 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 7 syntheses or guidelines pooled it, 125 citations in OpenAlex.

  1. Pooled it
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  13. Effects of a 12-week home-based exercise program on the level of physical activity, insulin, and cytokines in colorectal cancer survivors: a pilot study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013
    Trial
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  18. Exercise therapy in cancer prevention and treatment.Nature reviews. Clinical oncology · 2026
    Review
  19. Physical activity, metabolites, and breast cancer associations.Journal of the National Cancer Institute · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 2 countries.

Christine M FriedenreichDepartment of Population Health Research, Alberta Health Services-Cancer Care, Calgary, Alberta, Canada T2N 4N2. christine.friedenreich@albertahealthservices.ca
Heather K Neilson
Christy G Woolcott
Anne McTiernan
Qinggang Wang
Rachel Ballard-Barbash
Charlotte A Jones
Frank Z Stanczyk
Rollin F Brant
Yutaka Yasui
Melinda L Irwin
Kristin L Campbell
Margaret L McNeely
Kristina H Karvinen
Kerry S Courneya
Alberta Health Services · CAUniversity of Alberta · CAUniversity of British Columbia · CADalhousie University · CAEast Carolina University · USFred Hutch Cancer Center · USNational Institutes of Health · USUniversity of Calgary · CAUniversity of Southern California · USYale University · US

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

Physical activity is a known modifiable lifestyle means for reducing postmenopausal breast cancer risk, but the biologic mechanisms are not well understood. Metabolic factors may be involved. In this study, we aimed to determine the effects of exercise on insulin resistance (IR) indicators, IGF1, and adipokines in postmenopausal women. The Alberta Physical Activity and Breast Cancer Prevention Trial was a two-armed randomized controlled trial in postmenopausal, inactive, cancer-free women. A year-long aerobic exercise intervention of 225  min/week (n=160) was compared with a control group asked to maintain usual activity levels (n=160). Baseline, 6- and 12-month serum levels of insulin, glucose, IGF1, IGF-binding protein 3 (IGFBP3), adiponectin, and leptin were assayed, and after data collection, homeostasis model assessment of IR (HOMA-IR) scores were calculated. Intention-to-treat analyses were performed using linear mixed models. The treatment effect ratio (TER) of exercisers to controls was calculated. Data were available on 308 (96.3%) women at 6 months and 310 (96.9%) women at 12 months. Across the study period, statistically significant reductions in insulin (TER=0.87, 95% confidence interval (95% CI)=0.81-0.93), HOMA-IR (TER=0.86, 95% CI=0.80-0.93), and leptin (TER=0.82, 95% CI=0.78-0.87), and an increase in the adiponectin/leptin ratio (TER=1.21, 95% CI=1.13-1.28) were observed in the exercise group compared with the control group. No significant differences were observed for glucose, IGF1, IGFBP3, adiponectin or the IGF1/IGFBP3 ratio. Previously inactive postmenopausal women who engaged in a moderate-to-vigorous intensity exercise program experienced changes in insulin, HOMA-IR, leptin, and adiponectin/leptin that might decrease the risk for postmenopausal breast cancer.

Indexed as

AdipokinesAgedBiomarkersBreast NeoplasmsCarcinomaExerciseFemaleHumansInsulin ResistanceMiddle AgedPostmenopauseSomatomedinsTime FactorsAdipokinesBiomarkersSomatomedins

Identifiers

PMID21482635
PMCPMC3111235
OpenAlexW2144160519

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.