Evidence map›Paper›PMID 21482353›Full record

ReviewNeuron2011

Neural systems governed by nicotinic acetylcholine receptors: emerging hypotheses.

Julie M Miwa, Robert Freedman, Henry A Lester

Open access · bronzeAbstract readReview
In one paragraph

Review in Neuron, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 202 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Memory under siege: the cognitive costs of smoking and vaping.Brain, behavior, & immunity - health · 2025
    Review
  6. Continuous Nicotine Monitors for Personal Nicotine Pharmacokinetics: A Receptor-Aware Research Agenda.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Dual Role of the P2X7 Receptor in Dendritic Outgrowth during Physiological and Pathological Brain Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  17. The Role of Ghrelin/GHS-R1A Signaling in Nonalcohol Drug Addictions.International journal of molecular sciences · 2022
    Review
  18. Article
  19. ReducedFrontiers in cell and developmental biology · 2022
    Article
  20. Article

67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Julie M MiwaDivision of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA.
Robert Freedman
Henry A Lester
California Institute of Technology · USUniversity of Colorado Denver · US

Funding

NICOTINIC SYNAPSES, BIOPHYSICAL STUDIESR01NS011756 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI LESTER, HENRY A. · 1985 to 2009
$3.4M
RiboTag: A novel technique to profile cell type specific gene expression and invR01MH086386 · NIMH · UNIVERSITY OF WASHINGTON · PI MCKNIGHT, GEORGE STANLEY · 2009 to 2013
$1.9M
Chronic nicotine: cell-specific receptor and circuit alterations in basal gangliaR01AG033954 · NIA · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI LESTER, HENRY A. · 2009 to 2013
$1.7M
NIA NIH HHS AG-33954NIA NIH HHS R01 AG033954NIDA NIH HHS DA-11729NIMH NIH HHS MH-86386NIMH NIH HHS R01 MH086386NINDS NIH HHS NS-11756NINDS NIH HHS R01 NS011756
6 · The paper itself

Abstract

Cholinergic neurons and nicotinic acetylcholine receptors (nAChRs) in the brain participate in diverse functions: reward, learning and memory, mood, sensory processing, pain, and neuroprotection. Nicotinic systems also have well-known roles in drug abuse. Here, we review recent insights into nicotinic function, linking exogenous and endogenous manipulations of nAChRs to alterations in synapses, circuits, and behavior. We also discuss how these contemporary advances can motivate attempts to exploit nicotinic systems therapeutically in Parkinson's disease, cognitive decline, epilepsy, and schizophrenia.

Indexed as

AnimalsCholinergic FibersHumansNervous System DiseasesNeural PathwaysNeuronsReceptors, NicotinicReceptors, Nicotinic

Identifiers

PMID21482353
PMCPMC4418790
OpenAlexW2070740144

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.