Evidence map›Paper›PMID 21481636›Full record

ReviewTrends in immunology2011

Molecular aspects of epithelial γδ T cell regulation.

Deborah A Witherden, Wendy L Havran

Abstract readReview
In one paragraph

Review in Trends in immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Epidermal resident γδ T cell development and function in skin.Cellular and molecular life sciences : CMLS · 2021
    Review
  6. Protective Role ofJournal of immunology research · 2018
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Deborah A WitherdenDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Wendy L Havran
Scripps Research Institute · US

Funding

JAML: A New Costimulatory Molecule for Gamma Delta T CellsR01AI064811 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI HAVRAN, WENDY L. · 2006 to 2016
$4.8M
EPITHELIAL T CELL SECRETION OF TISSUE SPECIFIC CYTOKINESR01AI036964 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI HAVRAN, WENDY L. · 1996 to 2012
$3.7M
Gamma delta T cells and human wound healingR01GM080301 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI HAVRAN, WENDY L. · 2008 to 2011
$1.7M
NIAID NIH HHS AI036964NIAID NIH HHS AI64811NIAID NIH HHS R01 AI036964NIAID NIH HHS R01 AI064811NIGMS NIH HHS GM080301NIGMS NIH HHS R01 GM080301
6 · The paper itself

Abstract

γδ T cells lie at the interface between innate and adaptive immunity, sharing features with both arms of the immune system. The vast majority of γδ T cells reside in epithelial layers of tissues such as skin, gut, lung, tongue and reproductive tract where they provide a first line of defense against environmental attack. The existence of epithelium-resident γδ T cells has been known for over 20 years but our understanding of the molecular events regulating development and function of these cells is incomplete. We review recent advances in the field, with particular emphasis on the γδ T cell population resident in mouse epidermis. These studies have enhanced our knowledge and understanding of the life cycle of this enigmatic population of cells.

Indexed as

AnimalsCell DifferentiationCell LineageEpithelial CellsHumansReceptors, Antigen, T-Cell, gamma-deltaT-LymphocytesReceptors, Antigen, T-Cell, gamma-delta

Identifiers

PMID21481636
PMCPMC3109268
OpenAlexW2147231753

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.