ArticlePsychoneuroendocrinology2011
Neuroanatomical evidence for reciprocal regulation of the corticotrophin-releasing factor and oxytocin systems in the hypothalamus and the bed nucleus of the stria terminalis of the rat: Implications for balancing stress and affect.
Article in Psychoneuroendocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
128 citing papers in PubMed, 1 synthesis or guideline pooled it, 276 citations in OpenAlex.
- Coordination of social behaviors by the bed nucleus of the stria terminalis.The European journal of neuroscience · 2022Pooled it
- Oxytocin levels in response to CRH administration in hypopituitarism and hypothalamic damage: a randomized, crossover, placebo-controlled trial.Scientific reports · 2025Trial
- Oxytocin, cortisol, and cognitive control during acute and naturalistic stress.Stress (Amsterdam, Netherlands) · 2021Trial
- Oxytocin modulates behavioral and physiological responses to a stressor in marmoset monkeys.Psychoneuroendocrinology · 2016Trial
- Intranasal administration of oxytocin increases compassion toward women.Social cognitive and affective neuroscience · 2015Trial
- Oxytocin increases anxiety to unpredictable threat.Molecular psychiatry · 2013Trial
- Psychoneuroendocrine Associations with Momentary Pelvic Pain in Endometriosis.International journal of behavioral medicine · 2026Article
- Activity of Corticotropin-Releasing Factor Neurons in the Bed Nucleus of the Stria Terminalis Reduces Anxiety-Potentiated Startle in Female Rats in an Estrous Phase-Dependent Manner.Biological psychiatry · 2026Article
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- Oxytocin Deficiency in Childhood and Adolescence: Clinical Features, Diagnostic Challenges and Therapeutic Perspectives.Current issues in molecular biology · 2025Review
- Development of a Methodology for Measuring Oxytocin in Feces: Insights from a Preliminary Study in Captive Lions (Animals : an open access journal from MDPI · 2025Article
- From trauma to resilience: psychological and epigenetic adaptations in the third generation of holocaust survivors.Scientific reports · 2025Article
- The Oxytocin System and Implications for Oxytocin Deficiency in Hypothalamic-Pituitary Disease.Endocrine reviews · 2025Review
- Vasopressin and oxytocin excite BNST neurons via oxytocin receptors, which reduce anxious arousal.Cell reports · 2025Article
- Navigating Central Oxytocin Transport: Known Realms and Uncharted Territories.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025Review
- Distinct oxytocin signaling pathways synergistically mediate rescue-like behavior in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The Relationship Between Oxytocin and Alcohol Dependence.Current topics in behavioral neurosciences · 2025Review
- Abscisic acid regulates maternal behavior in rats via PPARγ receptors and hypothalamic oxytocin signaling.Iranian journal of veterinary research · 2025Article
- Molecular and functional mapping of the neuroendocrine hypothalamus: a new era begins.Journal of endocrinological investigation · 2024Review
68 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Activation of corticotrophin releasing factor (CRF) neurons in the paraventricular nucleus of the hypothalamus (PVN) is necessary for establishing the classic endocrine response to stress, while activation of forebrain CRF neurons mediates affective components of the stress response. Previous studies have reported that mRNA for CRF2 receptor (CRFR2) is expressed in the bed nucleus of the stria terminalis (BNST) as well as hypothalamic nuclei, but little is known about the localization and cellular distribution of CRFR2 in these regions. Using immunofluorescence with confocal microscopy, as well as electron microscopy, we demonstrate that in the BNST CRFR2-immunoreactive fibers represent moderate to strong labeling on axons terminals. Dual-immunofluorescence demonstrated that CRFR2-fibers co-localize oxytocin (OT), but not arginine-vasopressin (AVP), and make perisomatic contacts with CRF neurons. Dual-immunofluorescence and single cell RT-PCR demonstrate that in the hypothalamus, CRFR2 immunoreactivity and mRNA are found in OT, but not in CRF or AVP-neurons. Furthermore, CRF neurons of the PVN and BNST express mRNA for the oxytocin receptor, while the majority of OT/CRFR2 neurons in the hypothalamus do not. Finally, using adenoviral-based anterograde tracing of PVN neurons, we show that OT/CRFR2-immunoreactive fibers observed in the BNST originate in the PVN. Our results strongly suggest that CRFR2 located on oxytocinergic neurons and axon terminals might regulate the release of this neuropeptide and hence might be a crucial part of potential feedback loop between the hypothalamic oxytocin system and the forebrain CRF system that could significantly impact affective and social behaviors, in particular during times of stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.