Evidence map›Paper›PMID 21481374›Full record

ArticleFertility and sterility2011

Colony-stimulating factor-1 exerts direct effects on the proliferation and invasiveness of endometrial epithelial cells.

Sabitha Aligeti, Nameer B Kirma, Peter A Binkley, Robert S Schenken, Rajeshwar Rao Tekmal

Open access · bronzeAbstract read
In one paragraph

Article in Fertility and sterility, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sabitha AligetiDepartment of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.
Nameer B Kirma
Peter A Binkley
Robert S Schenken
Rajeshwar Rao Tekmal
The University of Texas Health Science Center at San Antonio · USThe University of Texas at San Antonio · US

Funding

CSF-1 and c-fms and the Early Endometriotic LesionR01HD049637 · NICHD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI TEKMAL, RAJESHWAR R · 2008 to 2010
$968k
NICHD NIH HHS R01 HD049637
6 · The paper itself

Abstract

Although macrophage colony-stimulating factor (CSF-1) has been suggested to play a role in maintaining the chronic inflammatory response in endometriosis, our data suggest that CSF-1 may also play a role in early endometriosis lesion formation. We have shown that CSF-1, in an autocrine fashion, has a direct effect on endometrial epithelial cell proliferation and attachment to peritoneal mesothelial cells, early steps in endometriosis lesion formation on the peritoneum.

Indexed as

Cell MovementCell ProliferationAnalysis of VarianceAutocrine CommunicationCell AdhesionCell LineCoculture TechniquesEndometriosisEndometriumEpithelial CellsFemaleHumansMacrophage Colony-Stimulating FactorPeritoneumRNA InterferenceTime FactorsMacrophage Colony-Stimulating Factor

Identifiers

PMID21481374
PMCPMC3124585
OpenAlexW2057354912

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.