ArticleMolecular microbiology2011
Expression hierarchy in the Yersinia type III secretion system established through YopD recognition of RNA.
Article in Molecular microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Class II chaperones: indispensable components of the Gram-negative bacterial T3SS as guardians of translocators.Archives of microbiology · 2026Review
- Fis suppresses late-stage virulence gene expression in Yersinia pseudotuberculosis at environmental temperatures.PLoS pathogens · 2026Article
- Article
- Pathogenicity and virulence ofVirulence · 2024Review
- RNase-mediated reprogramming of Yersinia virulence.PLoS pathogens · 2024Article
- Sex differences in immune protection in mice conferred by heterologous vaccines for pneumonic plague.Frontiers in immunology · 2024Article
- Macrophage innate immune responses delineate between defective translocon assemblies produced byVirulence · 2023Article
- Functional assays to screen and select monoclonal antibodies that targetHuman vaccines & immunotherapeutics · 2023Article
- The Regulatory Circuit Underlying Downregulation of a Type III Secretion System inInternational journal of molecular sciences · 2022Article
- Article
- Global discovery of bacterial RNA-binding proteins by RNase-sensitive gradient profiles reports a new FinO domain protein.RNA (New York, N.Y.) · 2020Article
- A bacterial secreted translocator hijacks riboregulators to control type III secretion in response to host cell contact.PLoS pathogens · 2019Article
- Discovering RNA-Based Regulatory Systems forFrontiers in cellular and infection microbiology · 2018Review
- Heterologous Complementation Studies With the YscX and YscY Protein Families Reveals a Specificity forFrontiers in cellular and infection microbiology · 2018Article
- A systematic analysis of the RNA-targeting potential of secreted bacterial effector proteins.Scientific reports · 2017Article
- RNA-based mechanisms of virulence control in Enterobacteriaceae.RNA biology · 2017Review
- Yersinia Type III Secretion System Master Regulator LcrF.Journal of bacteriology · 2015Review
- Regulatory principles governing Salmonella and Yersinia virulence.Frontiers in microbiology · 2015Review
- Random mutagenesis identifies a C-terminal region of YopD important for Yersinia type III secretion function.PloS one · 2015Article
- RNA-binding proteins involved in post-transcriptional regulation in bacteria.Frontiers in microbiology · 2015Review
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2 authors.
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Abstract
The Yersinia type III secretion system (T3SS) is environmentally responsive to enable its rapid induction upon contact with host cells and is necessary for Yersiniae to establish a replicative niche and cause disease. YopD, a translocator protein, represses the expression of T3SS genes until signalled by environmental cues, a mechanism known as the low calcium response. In this work, we investigated recognition of target genes by Yersinia pestis YopD. Expression of all genes of the T3SS was induced in a yopD mutant, though not to the same degree, with effector Yops most affected. Two, short AU-rich sequence elements up- and downstream of start codons of target genes were necessary but not sufficient for YopD mediated repression. Purified YopD-LcrH bound specifically to target RNAs in vitro with different relative affinities, with effector Yops having greater affinity. Together, the data suggest YopD binds to T3SS transcripts where it may prevent ribosome binding causing accelerated mRNA degradation. This regulatory mechanism may ensure an expression hierarchy during the low calcium response as low affinity YopD targets such as chaperones would be translated prior to high affinity targets such as effector Yops allowing the bacteria another layer of control over Yop translocation during infection.
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