ReviewBritish journal of pharmacology2011
Animal models to guide clinical drug development in ADHD: lost in translation?
Review in British journal of pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Behavioural effects of methylphenidate in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder: a systematic review and meta-analysis protocol.BMJ open science · 2018Pooled it
- A randomized, double-blind, placebo-controlled crossover study of α4β 2* nicotinic acetylcholine receptor agonist AZD1446 (TC-6683) in adults with attention-deficit/hyperactivity disorder.Psychopharmacology · 2014Trial
- Using rodent data to elucidate dopaminergic mechanisms of ADHD: Implications for human personality.Personality neuroscience · 2024Review
- A Novel Rat Model of ADHD-like Hyperactivity/Impulsivity after Delayed Reward Has Selective Loss of Dopaminergic Neurons in the Right Ventral Tegmental Area.International journal of molecular sciences · 2023Article
- Methylphenidate as a causal test of translational and basic neural coding hypotheses.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Attention-Deficit/Hyperactivity Disorder Predominantly Inattentive Subtype/Presentation: Research Progress and Translational Studies.Brain sciences · 2020Review
- Hyperactivity in mice lacking one allele of the glutamic acid decarboxylase 67 gene.Attention deficit and hyperactivity disorders · 2018Article
- Instrumental conditioning for food reinforcement in the spontaneously hypertensive rat model of attention deficit hyperactivity disorder.BMC research notes · 2017Article
- Theory of Visual Attention (TVA) applied to mice in the 5-choice serial reaction time task.Psychopharmacology · 2017Article
- Age-dependent, lasting effects of methylphenidate on the GABAergic system of ADHD patients.NeuroImage. Clinical · 2017Article
- The Effects of Perinatal Oxycodone Exposure on Behavioral Outcome in a Rodent Model.Frontiers in pediatrics · 2017Article
- Longitudinal magnetic resonance imaging reveals striatal hypertrophy in a rat model of long-term stimulant treatment.Translational psychiatry · 2016Article
- D-amphetamine improves attention performance in adolescent Wistar, but not in SHR rats, in a two-choice visual discrimination task.Psychopharmacology · 2015Article
- Effect of diet on brain metabolites and behavior in spontaneously hypertensive rats.Behavioural brain research · 2014Article
- Amphetamine, past and present--a pharmacological and clinical perspective.Journal of psychopharmacology (Oxford, England) · 2013Review
- Impulsive choice behavior in four strains of rats: evaluation of possible models of Attention-Deficit/Hyperactivity Disorder.Behavioural brain research · 2013Article
- Physical exercise and catecholamine reuptake inhibitors affect orienting behavior and social interaction in a rat model of attention-deficit/hyperactivity disorder.Behavioral neuroscience · 2012Article
- Reinforcement, dopamine and rodent models in drug development for ADHD.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2012Review
- From basic to clinical neuropharmacology: targetophilia or pharmacodynamics?British journal of clinical pharmacology · 2012Review
- Translational neuropharmacology and the appropriate and effective use of animal models.British journal of pharmacology · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We review strategies for developing animal models for examining and selecting compounds with potential therapeutic benefit in attention-deficit hyperactivity disorder (ADHD). ADHD is a behavioural disorder of unknown aetiology and pathophysiology. Current understanding suggests that genetic factors play an important role in the aetiology of ADHD. The involvement of dopaminergic and noradrenergic systems in the pathophysiology of ADHD is probable. We review the clinical features of ADHD including inattention, hyperactivity and impulsivity and how these are operationalized for laboratory study. Measures of temporal discounting (but not premature responding) appear to predict known drug effects well (treatment validity). Open-field measures of overactivity commonly used do not have treatment validity in human populations. A number of animal models have been proposed that simulate the symptoms of ADHD. The most commonly used are the spontaneously hypertensive rat (SHR) and the 6-hydroxydopamine-lesioned (6-OHDA) animals. To date, however, the SHR lacks treatment validity, and the effects of drugs on symptoms of impulsivity and inattention have not been studied extensively in 6-OHDA-lesioned animals. At the present stage of development, there are no in vivo models of proven effectiveness for examining and selecting compounds with potential therapeutic benefit in ADHD. However, temporal discounting is an emerging theme in theories of ADHD, and there is good evidence of increased value of delayed reward following treatment with stimulant drugs. Therefore, operant behaviour paradigms that measure the effects of drugs in situations of delayed reinforcement, whether in normal rats or selected models, show promise for the future.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.