Evidence map›Paper›PMID 21480629›Full record

ReviewChemical research in toxicology2011

Evolution of research on the DNA adduct chemistry of N-nitrosopyrrolidine and related aldehydes.

Stephen S Hecht, Pramod Upadhyaya, Mingyao Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chemical research in toxicology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. In vivo and in vitro genotoxicity of N-nitrosopyrrolidine following UVA irradiation.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stephen S HechtMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States. hecht002@umn.edu
Pramod Upadhyaya
Mingyao Wang

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Douglas Yee · 1998 to 2026
$100.4M
METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINESR01CA081301 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI STEPHEN S HECHT · 1999 to 2026
$7.1M
Metabolism of Carcinogenic Tobacco-Specific NitrosaminesR37CA081301 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HECHT, STEPHEN S · 2004 to 2013
$5.5M
CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTSR01CA085702 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HECHT, STEPHEN S · 2000 to 2010
$3.3M
NCI NIH HHS CA-77598NCI NIH HHS CA-81301NCI NIH HHS CA-85702NCI NIH HHS P30 CA077598NCI NIH HHS R01 CA081301NCI NIH HHS R01 CA085702NCI NIH HHS R37 CA081301
6 · The paper itself

Abstract

This perspective reviews our work on the identification of DNA adducts of N-nitrosopyrrolidine and some related aldehydes. The research began as a focused project to investigate mechanisms of cyclic nitrosamine carcinogenesis but expanded into other areas, as aldehyde metabolites of NPYR were shown to have their own diverse DNA adduct chemistry. A total of 69 structurally distinct DNA adducts were identified, and some of these, found in human tissues, have provided intriguing leads for investigating carcinogenesis mechanisms in humans due to exposure to both endogenous and exogenous agents.

Indexed as

AldehydesAnimalsDNADNA AdductsHumansN-NitrosopyrrolidineAldehydesDNADNA AdductsN-Nitrosopyrrolidine

Identifiers

PMID21480629
PMCPMC3118975

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.