ArticleMolecular carcinogenesis2011
Energy balance modulates colon tumor growth: Interactive roles of insulin and estrogen.
Article in Molecular carcinogenesis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Association of obesity with DNA mismatch repair status and clinical outcome in patients with stage II or III colon carcinoma participating in NCCTG and NSABP adjuvant chemotherapy trials.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2012Trial
- Caloric restriction reprograms skeletal muscle molecular pathways in non-human primates: potential relevance to human aging biology.Skeletal muscle · 2026Article
- Leptin Augments Antitumor Immunity in Obesity by Repolarizing Tumor-Associated Macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Obesity-associated leptin promotes chemoresistance in colorectal cancer through YAP-dependent AXL upregulation.American journal of cancer research · 2021Article
- Article
- Improvement of Colonic Immune Function with Soy Isoflavones in High-Fat Diet-Induced Obese Rats.Molecules (Basel, Switzerland) · 2019Article
- Type 2 diabetes and risk of colorectal cancer in two large U.S. prospective cohorts.British journal of cancer · 2018Article
- Effect of Weight Gain and Weight Loss on In Vivo Colonocyte Proliferation Rate in People with Obesity.Obesity (Silver Spring, Md.) · 2017Article
- Obesity and Cancer Mechanisms: Cancer Metabolism.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2016Review
- The Role of Bioactive Dietary Components in Modulating miRNA Expression in Colorectal Cancer.Nutrients · 2016Review
- Association of tamoxifen use and increased diabetes among Asian women diagnosed with breast cancer.British journal of cancer · 2014Article
- Article
- Synergistic effect of fadrozole and insulin-like growth factor-I on female-to-male sex reversal and body weight of broiler chicks.PloS one · 2014Article
- Abdominal obesity, independent from caloric intake, accounts for the development of intestinal tumors in Apc(1638N/+) female mice.Cancer prevention research (Philadelphia, Pa.) · 2013Article
- Diet, obesity, and cancer progression: are adipocytes the link?Lipid insights · 2013Review
- The role of chronic inflammation in obesity-associated cancers.ISRN oncology · 2013Article
- Genetic variation in insulin pathway genes and distal colorectal adenoma risk.International journal of colorectal disease · 2012Article
- The role of adiponectin in cancer: a review of current evidence.Endocrine reviews · 2012Review
- Article
- Adult BMI Change and Risk of Colon Cancer in Postmenopausal Women.Journal of obesity · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Obesity increases colorectal cancer (CRC) risk and progression. However, the impact of obesity on CRC in women is dependent on ovarian hormone status. The purpose of this study was to determine the interactive roles of obesity and ovarian hormones on serum markers of inflammation, cell signaling, and transplanted colon tumor growth. Female C57BL/6 mice (6 wk) were either ovariectomized (OVX) or ovaries left intact (nonovariectomized, NOVX) and randomized to receive a (1) control, (2) 30% calorie-restricted (CR), or (3) diet-induced obese (DIO) diet regimen for 20 wk to induce differing levels of adiposity. Serum was collected and inflammatory and metabolic markers were measured using an antibody array (62 proteins) and ELISAs. Mice were subcutaneously injected with syngeneic MC38 colon cancer cells after 20 wk and sacrificed 4 wk later. CR mice had the smallest tumors irrespective of hormone status, whereas the largest tumors were observed in DIO-OVX mice. Glucose tolerance was impaired in OVX mice, being most severe in the DIO-OVX group. Cytokine arrays suggested that in CR animals, inhibition of tumor growth paralleled insulin sensitivity and associated changes in leptin, adiponectin, and IGF-BPs. Conversely, in DIO-OVX animals, tumor growth was associated with insulin and leptin resistance as well as higher levels of pro-inflammatory proteins. In vitro, leptin and adiponectin had no effect, whereas insulin induced MC38 cell proliferation and MAPK activation. Co-treatment with estrogen blocked the stimulatory effects of insulin. Thus, our in vitro and in vivo data indicate female reproductive hormones have a modulating effect on obesity-induced insulin resistance and inflammation, which may directly or indirectly influence CRC progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.