ArticleThe Journal of pathology2011
Development of metastatic HER2(+) breast cancer is independent of the adaptive immune system.
Article in The Journal of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Vaccination with autologous dendritic cells loaded with autologous tumor lysate or homogenate combined with immunomodulating radiotherapy and/or preleukapheresis IFN-α in patients with metastatic melanoma: a randomised "proof-of-principle" phase II study.Journal of translational medicine · 2014Trial
- Reshaping the tumor immune microenvironment to improve CAR-T cell-based cancer immunotherapy.Molecular cancer · 2024Review
- De novo necroptosis creates an inflammatory environment mediating tumor susceptibility to immune checkpoint inhibitors.Communications biology · 2020Article
- Immunogenicity of rat-neuScientific reports · 2020Article
- The Immune Revolution: A Case for Priming, Not Checkpoint.Cancer cell · 2018Review
- Article
- IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis.Nature · 2015Article
- Interleukin-15 is required for immunosurveillance and immunoprevention of HER2/neu-driven mammary carcinogenesis.Breast cancer research : BCR · 2015Article
- Tertiary lymphoid structures are associated with higher tumor grade in primary operable breast cancer patients.BMC cancer · 2015Article
- Tumor immunotherapy: lessons from autoimmunity.Frontiers in immunology · 2014Review
- Induction of Wnt-inducible signaling protein-1 correlates with invasive breast cancer oncogenesis and reduced type 1 cell-mediated cytotoxic immunity: a retrospective study.PLoS computational biology · 2014Article
- Immunological effects of chemotherapy in spontaneous breast cancers.Oncoimmunology · 2013Article
- Prognostic role of interleukin-6, interleukin-8, and leptin levels according to breast cancer subtype.Cancer research and treatment · 2013Article
- Cancer heterogeneity--a multifaceted view.EMBO reports · 2013Review
- The biology of personalized cancer medicine: facing individual complexities underlying hallmark capabilities.Molecular oncology · 2012Review
- Article
- An evolutionary perspective on anti-tumor immunity.Frontiers in oncology · 2012Article
- Revisiting cancer immunoediting by understanding cancer immune complexity.The Journal of pathology · 2011Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tumour-modulating effects of the endogenous adaptive immune system are rather paradoxical. Whereas some clinical and experimental observations offer compelling evidence for the existence of immunosurveillance, other studies have revealed promoting effects of the adaptive immune system on primary cancer development and metastatic disease. We examined the functional significance of the adaptive immune system as a regulator of spontaneous HER2(+) breast tumourigenesis and pulmonary metastasis formation, using the MMTV-NeuT mouse model in which mammary carcinogenesis is induced by transgenic expression of the activated HER2/neu oncogene. Although T and B lymphocytes infiltrate human and experimental HER2(+) breast tumours, genetic elimination of the adaptive immune system does not affect development of premalignant hyperplasias or primary breast cancers. In addition, we demonstrate that pulmonary metastasis formation in MMTV-NeuT mice is not dependent on the adaptive immune system. Thus, our findings reveal that spontaneous HER2-driven mammary tumourigenesis and metastasis formation are neither suppressed, nor altered by immunosurveillance mechanisms, nor promoted by the adaptive immune system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.