ReviewCerebellum (London, England)2011
T-type calcium channel as a new therapeutic target for tremor.
Review in Cerebellum (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Role of Thalamic CaInternational journal of molecular sciences · 2025Article
- A Non-Invasive and DNA-free Approach to Upregulate Mammalian Voltage-Gated Calcium Channels and Neuronal Calcium Signaling via Terahertz Stimulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Modulation of CB1 cannabinoid receptor alters the electrophysiological properties of cerebellar Purkinje cells in harmaline-induced essential tremor.IBRO neuroscience reports · 2024Article
- CaInternational journal of molecular sciences · 2022Review
- Thalamic T-Type Calcium Channels as Targets for Hypnotics and General Anesthetics.International journal of molecular sciences · 2022Review
- Reduction of neuronal hyperexcitability with modulation of T-type calcium channel or SK channel in essential tremor.International review of neurobiology · 2022Review
- Zonisamide can ameliorate the voltage-dependence alteration of the T-type calcium channel CaMolecular brain · 2020Article
- Alterations in Oscillatory Behavior of Central Medial Thalamic Neurons Demonstrate a Key Role of CaV3.1 Isoform of T-Channels During Isoflurane-Induced Anesthesia.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Functional Antagonism of Sphingosine-1-Phosphate Receptor 1 Prevents Harmaline-Induced Ultrastructural Alterations and Caspase-3 Mediated Apoptosis.The Malaysian journal of medical sciences : MJMS · 2019Article
- Article
- T-type calcium channels functionally interact with spectrin (α/β) and ankyrin B.Molecular brain · 2018Article
- Switchable slow cellular conductances determine robustness and tunability of network states.PLoS computational biology · 2018Article
- Cannabinoid type 1 receptor antagonism ameliorates harmaline-induced essential tremor in rat.British journal of pharmacology · 2016Article
- Optimization of ADME Properties for Sulfonamides Leading to the Discovery of a T-Type Calcium Channel Blocker, ABT-639.ACS medicinal chemistry letters · 2015Article
- Protective effects of zonisamide against rotenone-induced neurotoxicity.Neurochemical research · 2013Article
- Unilateral Wing-Beating Tremor in Neuronal Intranuclear Inclusion Disease.Case reports in neurologyArticle
- Minocycline Mitigation of Tremor Syndrome and Defect of Cognitive and Balance Induced by Harmaline.Basic and clinical neuroscienceArticle
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Voltage-gated calcium channels play an important role in many physiological and pathological processes. Accumulating studies suggest that the T-type calcium channel is a potential target for the treatment of various neurological disorders, such as epilepsy, insomnia, and neuropathic pain. Here, we highlight recent advances in our understanding of T-type calcium channel regulation and their implications for tremor disorders. Several T-type calcium channel blockers effectively suppressed experimental tremors that have been suggested to originate from either the cerebellum or basal ganglia. Among T-type calcium channel blockers that have been used clinically, the anti-tremor efficacy of zonisamide garnered our attention. Based on both basic and clinical studies, the possibility is emerging that T-type calcium channel blockers that transit into the central nervous system may have therapeutic potentials for tremor disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.