ArticleTheoretical medicine and bioethics2011
The placebo phenomenon and medical ethics: rethinking the relationship between informed consent and risk-benefit assessment.
Article in Theoretical medicine and bioethics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Placebo Response in Randomised Controlled Trials of Systemic Therapies for Cutaneous Lupus Erythematosus: A Systematic Review and Meta-Analysis.Pharmaceutical medicine · 2026Pooled it
- Placebo Response and Its Predictors in Attention Deficit Hyperactivity Disorder: A Meta-Analysis and Comparison of Meta-Regression and MetaForest.The international journal of neuropsychopharmacology · 2022Pooled it
- Nonspecific adverse events in knee osteoarthritis clinical trials: a systematic review.PloS one · 2014Pooled it
- Nocebo effects by providing informed consent in shared decision making? Not necessarily: a randomized pilot-trial using an open-label placebo approach.BMC medical ethics · 2020Trial
- Pediatricians' approaches to communicating side effects: a national survey.European journal of pediatrics · 2026Article
- The Ethics of Set and Setting in Psychedelic Psychotherapy.Neuroethics · 2025Article
- Clinical neuroscience and neurobiology of placebo and nocebo effects.International review of neurobiology · 2025Review
- The Nocebo Effect.Annual review of pharmacology and toxicology · 2024Review
- Placebo effects in osteoarthritis: implications for treatment and drug development.Nature reviews. Rheumatology · 2023Review
- Current Technology Developments Can Improve the Quality of Research and Level of Evidence for Rehabilitation Interventions: A Narrative Review.Sensors (Basel, Switzerland) · 2023Review
- Use of Traditional Mongolian Medicine in Children with Concussion.Medicines (Basel, Switzerland) · 2022Article
- Attitudes Toward a Pre-authorized Concealed Opioid Taper: A Qualitative Analysis of Patient and Clinician Perspectives.Frontiers in psychiatry · 2022Article
- Nocebo Effects of Clinical Communication and Placebo Effects of Positive Suggestions on Respiratory Muscle Strength.Frontiers in psychology · 2022Article
- Avoidance of nocebo effects by coincident naming of treatment benefits during the medical interview for informed consent-Evidence from dynamometry.Frontiers in psychology · 2022Article
- Alternative dosing of exemestane in postmenopausal women with ER-positive breast cancer. Design and methods of a randomized presurgical trial.Contemporary clinical trials · 2021Article
- Patient and Provider Acceptability of a Patient Preauthorized Concealed Opioid Reduction.Pain medicine (Malden, Mass.) · 2021Article
- The Importance of Patient Expectations: A Mixed-Methods Study of U.S. Psychiatrists.Frontiers in psychiatry · 2021Article
- [Placebos and placeboids in clinical practice: conceptual and ethical considerations].Der Nervenarzt · 2020Review
- Nocebo Effects on Muscular Performance - An Experimental Study About Clinical Situations.Frontiers in pharmacology · 2019Article
- Placebos as a Source of Agency: Evidence and Implications.Frontiers in psychiatry · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
It has been presumed within bioethics that the benefits and risks of treatments can be assessed independently of information disclosure to patients as part of the informed consent process. Research on placebo and nocebo effects indicates that this is not true for symptomatic treatments. The benefits and risks that patients experience from symptomatic treatments can be shaped powerfully by information about these treatments provided by clinicians. In this paper we discuss the implications of placebo and nocebo research for risk-benefit assessment and informed consent.
Indexed as
Identifiers
21479794What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.