ReviewSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2011
Oropharyngeal candidiasis in head and neck cancer patients treated with radiation: update 2011.
Review in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 108 citations in OpenAlex.
- Fluconazole for Preventing Radiation-Induced Oral Mucositis: A Randomized Controlled Trial.Head & neck · 2025Trial
- Efficacy of gel-based artificial saliva on Candida colonization and saliva properties in xerostomic post-radiotherapy head and neck cancer patients: a randomized controlled trial.Clinical oral investigations · 2021Trial
- Radiation-induced oral side effects in head and neck cancer: a scoping review and interdisciplinary recommendations.BMC oral health · 2026Article
- Review
- Fluconazole tolerance is associated with altered extracellular vesicle-mediated epithelial immune responses inFrontiers in microbiology · 2026Article
- Salivary metabolite-based prediction of radiotherapy-induced oral mucositis and candidiasis.Clinical oral investigations · 2025Article
- CARWL score as a predictor of radiation-induced periodontitis in locally advanced head and neck cancer undergoing concurrent chemoradiotherapy.Biomolecules & biomedicine · 2025Article
- Oropharyngeal candidiasis during radiotherapy for head and neck cancer: an observational study on prevalence, pain, and risk factors.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Observational
- Signs and symptoms of oral candidiasis associated with health factors and resistantFrontiers in oral health · 2025Article
- Investigating The Antifungal Activity of Atorvastatin Compared with Nystatin on Oral Candidiasis before and during Head and Neck Radiotherapy.Galen medical journal · 2024Review
- Antifungal effect of atorvastatin in comparison with fluconazole onDental research journal · 2024Article
- Salivary IgA as a Surrogate Biomarker for Microbial Infections in Postoperative Patients Receiving Chemo-Radio-Therapy for Head and Neck Cancer.Journal of laboratory physicians · 2023Article
- Predominance of non-BMJ open · 2023Article
- Diagnosis of OralArchives of Razi Institute · 2023Article
- Evaluation of virulence factors and azole resistance mechanisms ofIranian journal of microbiology · 2023Article
- Comparison of oral candidiasis characteristics in head-and-neck cancer patients before and during radiotherapy.Dental research journal · 2023Article
- Type II taste cells participate in mucosal immune surveillance.PLoS biology · 2023Article
- Oral infections in oral cancer survivors: A mini-review.Frontiers in oral health · 2022Review
- An underestimated pitfall of oral candidiasis in head and neck cancer patients undergoing radiotherapy: an observation study.BMC oral health · 2021Article
- Breakdown of Symbiosis in Radiation-Induced Oral Mucositis.Journal of fungi (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOropharyngeal candidiasis (OPC) is a major cause of morbidity in patients with malignancies. It is a common complication of head and neck radiation therapy and can result in pain, dysgeusia (taste changes), anorexia, malnutrition, and esophageal or systemic dissemination. Clinicians should be aware of current epidemiology, elements of diagnosis, and therapeutic trials guiding the recent recommendations for prophylaxis and management of OPC, a disease often incorrectly perceived as benign.
methodsThis review discusses OPC with focus in head and neck cancer patients receiving radiotherapy.
resultsLocal treatments are recommended as first-line therapy in milder forms of OPC. In the setting of local therapy, products that provide prolonged contact time and are not sucrose sweetened may result in successful prevention and management with low risk of oral/dental complications.
conclusionDiagnosis and management of OPC is required in head and neck cancer patients treated with radiation. Local therapy is suggested as first-line treatment for OPC, unless severe clinical infection or high risk immune suppression necessitate systemic therapy. The availability of effective locally delivered (topical) medications may provide potential for prophylaxis for carriers of Candida species in head and cancer patients during radiation therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.