Trial reportClinical oral investigations2012
Sealing occlusal caries lesions in adults referred for restorative treatment: 2-3 years of follow-up.
Trial report in Clinical oral investigations, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04127357 (Progression of Active Microcavitated Carious Lesions on Primary Teeth Occlusal Surfaces), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Progression of Active Microcavitated Carious Lesions on Primary Teeth Occlusal Surfaces: Randomize Clinical Trial
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Scientific evidence for the management of dentin caries lesions in pediatric dentistry: A systematic review and network meta-analysis.PloS one · 2018Pooled it
- 24-month efficacy of bioactive versus fluoride sealant for non-cavitated occlusal caries in adults: a randomized clinical trial.Scientific reports · 2025Trial
- Comparing the effectiveness of caries arrest by micro-operative treatment to operative treatment: A 2-year randomized controlled clinical trial.Clinical oral investigations · 2024Trial
- Selective vs stepwise removal of deep carious lesions in primary molars: 24 months follow-up from a randomized controlled trial.Clinical oral investigations · 2021Trial
- Is preventing micro-cavities in dentine from progressing with a sealant successful?British dental journal · 2019Trial
- Partial caries removal in deep caries lesions: a 5-year multicenter randomized controlled trial.Clinical oral investigations · 2018Trial
- Sealing versus partial caries removal in primary molars: a randomized clinical trial.BMC oral health · 2014Trial
- Management of deep caries.British dental journal · 2026Review
- Are resin sealants effective to treat caries lesions in the outer 1/3 of dentin compared to composite resin restorations? Systematic review and meta-analysis.The Japanese dental science review · 2025Review
- Micro-CT Assessment of Heat and Vibration Effect on Sealant Penetration in Different Fissure Types.Oral health & preventive dentistry · 2025Article
- Article
- Equivalence study of the resin-dentine interface of internal tunnel restorations when using an enamel infiltrant resin with ethanol-wet dentine bonding.Scientific reports · 2024Article
- The Assessment of Sealants' Effectiveness in Arresting Non-Cavitated Caries Lesion-A 24-Month Follow-Up.Healthcare (Basel, Switzerland) · 2022Article
- Minimally Invasive Therapies for the Management of Dental Caries-A Literature Review.Dentistry journal · 2021Review
- When to intervene in the caries process? A Delphi consensus statement.British dental journal · 2020Article
- When to intervene in the caries process? An expert Delphi consensus statement.Clinical oral investigations · 2019Article
- Pit and Fissure Sealants-A Comprehensive Review.Dentistry journal · 2018Review
- Dentists' attitudes and behaviour regarding deep carious lesion management: a multi-national survey.Clinical oral investigations · 2017Article
- Comparative Evaluation of the Marginal Sealing Ability of two Commercially Available Pit and Fissure Sealants.Journal of clinical and diagnostic research : JCDR · 2016Article
- Marginal and internal analysis of preheated dental fissure-sealing materials using optical coherence tomography.International dental journal · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to assess the possibility to arrest occlusal caries lesions in adults by sealant as well as to assess the presence of radiographic progression, arrest, and regression of the sealed lesions. Seventy-two occlusal caries lesions in 52 adult patients referred to restorative treatment by senior lecturers at School of Dentistry, Copenhagen, Denmark were included. In case the patient had more than one occlusal caries lesion, randomization between sealing and restoration was made; otherwise, the lesion was sealed. In total, 60 resin sealants and 12 composite restorations were made. Follow-up period was 25-38 months (mean = 33 months). Data were analyzed using non-parametric statistics including kappa statistics. After 2-3 years, the dropout rate was 15%; two patients did not show up for control and nine previously sealed lesions were restored by the patients' general practitioners. All 12 restorations and 39 of the remaining 49 sealants were well functioning, seven (14%) sealants were repaired/replaced due to failure, and three (6%) sealed lesions were restored due to caries progression (p > 0.05). The radiographic assessment showed caries progression beneath five (10%) sealants, caries regression beneath one (2%) sealant, and unchanged depth beneath 43 (88%) sealants and all restorations (p > 0.05). The majority of the referred lesions were successfully arrested by sealants, indicating the possibility for extending the criteria for sealing occlusal caries lesions in adults. However, a longer observation period is needed for final conclusion. Extending the criteria of therapeutic sealing of occlusal caries lesions in adults will lead to increased dental health.
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