ArticleLab on a chip2011
A single-layer, planar, optofluidic Mach-Zehnder interferometer for label-free detection.
Article in Lab on a chip, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Practical and Compact Guided Mode Resonance Sensing System for Highly Sensitive Real-Time Detection.Sensors (Basel, Switzerland) · 2025Article
- Sensitivity Improvement of Multi-Slot Subwavelength Bragg Grating Refractive Index Sensors by Increasing the Waveguide Height or Suspending the Sensor.Sensors (Basel, Switzerland) · 2022Article
- Article
- New routes to the functionalization patterning and manufacture of graphene-based materials for biomedical applications.Interface focus · 2018Article
- Liquid Core ARROW Waveguides: A Promising Photonic Structure for Integrated Optofluidic Microsensors.Micromachines · 2016Review
- Laser Scanning Holographic Lithography for Flexible 3D Fabrication of Multi-Scale Integrated Nano-structures and Optical Biosensors.Scientific reports · 2016Article
- Plasmofluidics: Merging Light and Fluids at the Micro-/Nanoscale.Small (Weinheim an der Bergstrasse, Germany) · 2015Review
- Optofluidic imaging: now and beyond.Lab on a chip · 2013Article
- A droplet-based, optofluidic device for high-throughput, quantitative bioanalysis.Analytical chemistry · 2012Article
- Detection of Dissolved Lactose Employing an Optofluidic Micro-System.Diagnostics (Basel, Switzerland) · 2012Article
- Optofluidic detection for cellular phenotyping.Lab on a chip · 2012Review
- A single-layer, planar, optofluidic switch powered by acoustically driven, oscillating microbubbles.Applied physics letters · 2012Article
- Single-shot characterization of enzymatic reaction constants Km and kcat by an acoustic-driven, bubble-based fast micromixer.Analytical chemistry · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We have developed a planar, optofluidic Mach-Zehnder interferometer for the label-free detection of liquid samples. In contrast to most on-chip interferometers which require complex fabrication, our design was realized via a simple, single-layer soft lithography fabrication process. In addition, a single-wavelength laser source and a silicon photodetector were the only optical equipment used for data collection. The device was calibrated using published data for the refractive index of calcium chloride (CaCl(2)) in solution, and the biosensing capabilities of the device were tested by detecting bovine serum albumin (BSA). Our design enables a refractometer with a low limit of detection (1.24 × 10(-4) refractive index units (RIU)), low variability (1 × 10(-4) RIU), and high sensitivity (927.88 oscillations per RIU). This performance is comparable to state-of-the-art optofluidic refractometers that involve complex fabrication processes and/or expensive, bulky optics. The advantages of our device (i.e. simple fabrication process, straightforward optical equipment, low cost, and high detection sensitivity) make it a promising candidate for future mass-producible, inexpensive, highly sensitive, label-free optical detection systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.