ArticlePloS one2011
Importin α7 is essential for zygotic genome activation and early mouse development.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Zika virus recruits karyopherin α6 for efficient replication via NS2B.Journal of virology · 2026Article
- Single-cell multiomic analysis reveals methylome and transcriptome deviations following oocyte maturation in vitro.Reproduction (Cambridge, England) · 2025Article
- Article
- The maternal-to-zygotic transition: reprogramming of the cytoplasm and nucleus.Nature reviews. Genetics · 2025Review
- Normal male fertility in a mouse model of KPNA2 deficiency.PloS one · 2024Article
- Loss of the importiniScience · 2023Article
- Maternal TDP-43 interacts with RNA Pol II and regulates zygotic genome activation.Nature communications · 2023Article
- Maternal effect factors that contribute to oocytes developmental competence: an update.Journal of assisted reproduction and genetics · 2022Review
- Structural characterization of human importin alpha 7 in its cargo-free form at 2.5 Å resolution.Scientific reports · 2022Article
- Kpna6 deficiency causes infertility in male mice by disrupting spermatogenesis.Development (Cambridge, England) · 2021Article
- Importin α5 Regulates Anxiety through MeCP2 and Sphingosine Kinase 1.Cell reports · 2018Article
- Karyopherin α-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Importin α: functions as a nuclear transport factor and beyond.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2018Review
- Importin α1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons.PLoS pathogens · 2018Article
- The Role of Maternal-Effect Genes in Mammalian Development: Are Mammalian Embryos Really an Exception?Stem cell reviews and reports · 2016Review
- Targeting Importin-α7 as a Therapeutic Approach against Pandemic Influenza Viruses.Journal of virology · 2015Article
- Diversification of importin-α isoforms in cellular trafficking and disease states.The Biochemical journal · 2015Review
- Article
- Importin-α7 is required for enhanced influenza A virus replication in the alveolar epithelium and severe lung damage in mice.Journal of virology · 2014Article
- Identification of importin α 7 specific transport cargoes using a proteomic screening approach.Molecular & cellular proteomics : MCP · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Importin α is involved in the nuclear import of proteins. It also contributes to spindle assembly and nuclear membrane formation, however, the underlying mechanisms are poorly understood. Here, we studied the function of importin α7 by gene targeting in mice and show that it is essential for early embryonic development. Embryos lacking importin α7 display a reduced ability for the first cleavage and arrest completely at the two-cell stage. We show that the zygotic genome activation is severely disturbed in these embryos. Our findings indicate that importin α7 is a new member of the small group of maternal effect genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.