ArticlePloS one2011
IL-1α mediated chorioamnionitis induces depletion of FoxP3+ cells and ileal inflammation in the ovine fetal gut.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 52 citations in OpenAlex.
- Association of Placental Pathology and Antibiotic Exposure after Birth with the Severity of Necrotizing Enterocolitis in Preterm Infants: A Case-Control Study.American journal of perinatology · 2026Article
- Impact of fetal inflammatory response on the severity of necrotizing enterocolitis in preterm infants.Pediatric research · 2024Article
- Paneth cell ontogeny in term and preterm ovine models.Frontiers in veterinary science · 2024Article
- Blockade of IL-6R prevents preterm birth and adverse neonatal outcomes.EBioMedicine · 2023Article
- Effects of multiple pro-inflammatory stimuliFrontiers in immunology · 2023Article
- Disrupted metabolic signatures in amniotic fluid associated with increased risk of intestinal inflammation in cesarean section offspring.Frontiers in immunology · 2023Article
- Detection of Volatile Organic Compounds as Potential Novel Biomarkers for Chorioamnionitis - Proof of Experimental Models.Frontiers in pediatrics · 2021Article
- The alarmin interleukin-1α causes preterm birth through the NLRP3 inflammasome.Molecular human reproduction · 2020Article
- The fetal inflammatory response syndrome: the origins of a concept, pathophysiology, diagnosis, and obstetrical implications.Seminars in fetal & neonatal medicine · 2020Article
- Increased Regulatory T Cells Precede the Development of Bronchopulmonary Dysplasia in Preterm Infants.Frontiers in immunology · 2020Observational
- Mechanisms of Fetal T Cell Tolerance and Immune Regulation.Frontiers in immunology · 2020Review
- Immunobiology of Acute Chorioamnionitis.Frontiers in immunology · 2020Review
- CD161 contributes to prenatal immune suppression of IFNγ-producing PLZF+ T cells.The Journal of clinical investigation · 2019Article
- Protection of the Ovine Fetal Gut againstNutrients · 2019Article
- Influence of vaginal lactoferrin administration on amniotic fluid cytokines and its role against inflammatory complications of pregnancy.Journal of inflammation (London, England) · 2017Article
- Fetal skin as a pro-inflammatory organ: Evidence from a primate model of chorioamnionitis.PloS one · 2017Article
- Regulatory T cell frequencies are increased in preterm infants with clinical early-onset sepsis.Clinical and experimental immunology · 2016Observational
- Intra-amniotic Candida albicans infection induces mucosal injury and inflammation in the ovine fetal intestine.Scientific reports · 2016Article
- Lipopolysaccharide-Induced Chorioamnionitis Promotes IL-1-Dependent Inflammatory FOXP3+ CD4+ T Cells in the Fetal Rhesus Macaque.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Clinical chorioamnionitis at term VI: acute chorioamnionitis and funisitis according to the presence or absence of microorganisms and inflammation in the amniotic cavity.Journal of perinatal medicine · 2016Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 4 countries.
Funding
Abstract
backgroundEndotoxin induced chorioamnionitis increases IL-1 and provokes an inflammatory response in the fetal ileum that interferes with intestinal maturation. In the present study, we tested in an ovine chorioamnionitis model whether IL-1 is a major cytokine driving the inflammatory response in the fetal ileum.
methodSheep bearing singleton fetuses received a single intraamniotic injection of recombinant ovine IL-1α at 7, 3 or 1 d before caesarian delivery at 125 days gestational age (term = 150 days).
results3 and 7 d after IL-1α administration, intestinal mRNA levels for IL-4, IL-10, IFN-γ and TNF-α were strongly elevated. Numbers of CD3+ and CD4+ T-lymphocytes and myeloidperoxidase+ cells were increased whereas FoxP3+ T-cells were detected at low frequency. This increased proinflammatory state was associated with ileal mucosal barrier loss as demonstrated by decreased levels of the intestinal fatty acid binding protein and disruption of the tight junctional protein ZO-1.
conclusionIntraamniotic IL-1α causes an acute detrimental inflammatory response in the ileum, suggesting that induction of IL-1 is a critical element in the pathophysiological effects of endotoxin induced chorioamnionitis. A disturbed balance between T-effector and FoxP3+ cells may contribute to this process.
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