ArticlePloS one2011
Assessment of a 44 gene classifier for the evaluation of chronic fatigue syndrome from peripheral blood mononuclear cell gene expression.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Influence of Chronic Fatigue Syndrome Codiagnosis on the Relationship between Perceived and Objective Psychoneuro-Immunoendocrine Disorders in Women with Fibromyalgia.Biomedicines · 2023Article
- Study on the Relationship between the miRNA-centered ceRNA Regulatory Network and Fatigue.Journal of molecular neuroscience : MN · 2021Review
- Lessons From Heat Stroke for Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.Frontiers in neurology · 2021Article
- Deep phenotyping of myalgic encephalomyelitis/chronic fatigue syndrome in Japanese population.Scientific reports · 2020Article
- Identification of actin network proteins, talin-1 and filamin-A, in circulating extracellular vesicles as blood biomarkers for human myalgic encephalomyelitis/chronic fatigue syndrome.Brain, behavior, and immunity · 2020Article
- Whole blood gene expression in adolescent chronic fatigue syndrome: an exploratory cross-sectional study suggesting altered B cell differentiation and survival.Journal of translational medicine · 2017Article
- RNA-Seq Analysis of Gene Expression, Viral Pathogen, and B-Cell/T-Cell Receptor Signatures in Complex Chronic Disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Biomarkers for Musculoskeletal Pain Conditions: Use of Brain Imaging and Machine Learning.Current rheumatology reports · 2017Review
- Illness progression in chronic fatigue syndrome: a shifting immune baseline.BMC immunology · 2016Article
- Article
- A Transcriptional Signature of Fatigue Derived from Patients with Primary Sjögren's Syndrome.PloS one · 2015Article
- High-throughput sequencing of plasma microRNA in chronic fatigue syndrome/myalgic encephalomyelitis.PloS one · 2014Article
- Differing leukocyte gene expression profiles associated with fatigue in patients with prostate cancer versus chronic fatigue syndrome.Psychoneuroendocrinology · 2013Article
- A Chronic Fatigue Syndrome (CFS) severity score based on case designation criteria.American journal of translational research · 2013Article
- Biomarkers for chronic fatigue.Brain, behavior, and immunity · 2012Review
- Genetics and Gene Expression Involving Stress and Distress Pathways in Fibromyalgia with and without Comorbid Chronic Fatigue Syndrome.Pain research and treatment · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic fatigue syndrome (CFS) is a clinically defined illness estimated to affect millions of people worldwide causing significant morbidity and an annual cost of billions of dollars. Currently there are no laboratory-based diagnostic methods for CFS. However, differences in gene expression profiles between CFS patients and healthy persons have been reported in the literature. Using mRNA relative quantities for 44 previously identified reporter genes taken from a large dataset comprising both CFS patients and healthy volunteers, we derived a gene profile scoring metric to accurately classify CFS and healthy samples. This metric out-performed any of the reporter genes used individually as a classifier of CFS.To determine whether the reporter genes were robust across populations, we applied this metric to classify a separate blind dataset of mRNA relative quantities from a new population of CFS patients and healthy persons with limited success. Although the metric was able to successfully classify roughly two-thirds of both CFS and healthy samples correctly, the level of misclassification was high. We conclude many of the previously identified reporter genes are study-specific and thus cannot be used as a broad CFS diagnostic.
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