ArticlePloS one2011
Identification of genes and genomic islands correlated with high pathogenicity in Streptococcus suis using whole genome tiling microarrays.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 27 citations in OpenAlex.
- Genomic analysis of a clinical Streptococcus suis ST1 isolate from CSF reveals antimicrobial resistance, virulence, and an evolutionary link to ST7.Scientific reports · 2026Article
- Investigation of genomic and pathogenicity characteristics ofEmerging microbes & infections · 2024Article
- Glycerol metabolism supports oral commensal interactions.The ISME journal · 2023Article
- Comparative transcriptomic analysis reveal genes involved in the pathogenicity increase ofVirulence · 2022Article
- Comparative analysis of Streptococcus suis genomes identifies novel candidate virulence-associated genes in North American isolates.Veterinary research · 2022Article
- Article
- Genomic and pathogenic investigations ofEmerging microbes & infections · 2021Article
- The global emergence of a novel Streptococcus suis clade associated with human infections.EMBO molecular medicine · 2021Article
- Genomic and ecological attributes of marine bacteriophages encoding bacterial virulence genes.BMC genomics · 2020Article
- Genomic Epidemiology ofPathogens (Basel, Switzerland) · 2019Article
- Genomic comparisons of Streptococcus suis serotype 9 strains recovered from diseased pigs in Spain and Canada.Veterinary research · 2018Article
- ANItools web: a web tool for fast genome comparison within multiple bacterial strains.Database : the journal of biological databases and curation · 2016Article
- Comparative metagenomics of biogas-producing microbial communities from production-scale biogas plants operating under wet or dry fermentation conditions.Biotechnology for biofuels · 2015Article
- Streptococcus suis infection: an emerging/reemerging challenge of bacterial infectious diseases?Virulence · 2014Review
- Comparative genomic hybridization identifies virulence differences in Streptococcus suis.PloS one · 2014Article
- Minimum core genome sequence typing of bacterial pathogens: a unified approach for clinical and public health microbiology.Journal of clinical microbiology · 2013Article
- Exacerbated type II interferon response drives hypervirulence and toxic shock by an emergent epidemic strain of Streptococcus suis.Infection and immunity · 2013Article
- Genetic analysis of capsular polysaccharide synthesis gene clusters from all serotypes of Streptococcus suis: potential mechanisms for generation of capsular variation.Applied and environmental microbiology · 2013Article
- Article
- Dual RNA-seq of pathogen and host.Nature reviews. Microbiology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
Streptococcus suis is an important zoonotic pathogen that can cause meningitis and sepsis in both pigs and humans. Infections in humans have been sporadic worldwide but two severe outbreaks occurred in China in recent years, while infections in pigs are a major problem in the swine industry. Some S. suis strains are more pathogenic than others with 2 sequence types (ST), ST1 and ST7, being well recognized as highly pathogenic. We analyzed 31 isolates from 23 serotypes and 25 STs by NimbleGen tiling microarray using the genome of a high pathogenicity (HP) ST1 strain, GZ1, as reference and a new algorithm to detect gene content difference. The number of genes absent in a strain ranged from 49 to 225 with a total of 632 genes absent in at least one strain, while 1346 genes were found to be invariably present in all strains as the core genome of S. suis, accounting for 68% of the GZ1 genome. The majority of genes are located in chromosomal blocks with two or more contiguous genes. Sixty two blocks are absent in two or more strains and defined as regions of difference (RDs), among which 26 are putative genomic islands (GIs). Clustering and statistical analyses revealed that 8 RDs including 6 putative GIs and 21 genes within these RDs are significantly associated with HP. Three RDs encode known virulence related factors including the extracellular factor, the capsular polysaccharide and a SrtF pilus. The strains were divided into 5 groups based on population genetic analysis of multilocus sequence typing data and the distribution of the RDs among the groups revealed gain and loss of RDs in different groups. Our study elucidated the gene content diversity of S. suis and identified genes that potentially promote HP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.