ArticlePloS one2011
Participation of the cell polarity protein PALS1 to T-cell receptor-mediated NF-κB activation.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Host PDZ-containing proteins targeted by SARS-CoV-2.The FEBS journal · 2021Article
- Common and distinctive localization patterns of Crumbs polarity complex proteins in the mammalian eye.Gene expression patterns : GEP · 2015Article
- Expression of polarity genes in human cancer.Cancer informatics · 2015Article
- Apico-basal polarity complex and cancer.Journal of biosciences · 2014Review
- Protease activated receptor-2 expression and function in asthmatic bronchial smooth muscle.PloS one · 2014Article
- Polarized cells, polarized views: asymmetric cell division in hematopoietic cells.Frontiers in immunology · 2014Review
- Polarity gene discs large homolog 1 regulates the generation of memory T cells.European journal of immunology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBeside their established function in shaping cell architecture, some cell polarity proteins were proposed to participate to lymphocyte migration, homing, scanning, as well as activation following antigen receptor stimulation. Although PALS1 is a central component of the cell polarity network, its expression and function in lymphocytes remains unknown. Here we investigated whether PALS1 is present in T cells and whether it contributes to T Cell-Receptor (TCR)-mediated activation. METHODOLOGY/PRINCIPAL
findingsBy combining RT-PCR and immunoblot assays, we found that PALS1 is constitutively expressed in human T lymphocytes as well as in Jurkat T cells. siRNA-based knockdown of PALS1 hampered TCR-induced activation and optimal proliferation of lymphocyte. We further provide evidence that PALS1 depletion selectively hindered TCR-driven activation of the transcription factor NF-κB.
conclusionsThe cell polarity protein PALS1 is expressed in T lymphocytes and participates to the optimal activation of NF-κB following TCR stimulation.
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