ArticlePLoS currents2011
Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington's Disease.
Article in PLoS currents, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- A comprehensive and standardized pipeline for automated profiling of higher cognition in mice.Cell reports methods · 2025Article
- Review
- Combined use of multiparametric high-content-screening and in vitro circadian reporter assays in neurotoxicity evaluation.Archives of toxicology · 2024Article
- Sex differences in sleep architecture in a mouse model of Huntington's disease.Journal of neuroscience research · 2024Article
- Sleep Disorders and Circadian Disruption in Huntington's Disease.Journal of Huntington's disease · 2023Review
- IntelliCage: the development and perspectives of a mouse- and user-friendly automated behavioral test system.Frontiers in behavioral neuroscience · 2023Review
- Sleep and Circadian Rhythm Dysfunction in Animal Models of Huntington's Disease.Journal of Huntington's disease · 2023Review
- Circadian dysfunction in the Q175 model of Huntington's disease: Network analysis.Journal of neuroscience research · 2019Article
- Article
- Automated tracking to measure behavioural changes in pigs for health and welfare monitoring.Scientific reports · 2017Article
- Neurocardiovascular deficits in the Q175 mouse model of Huntington's disease.Physiological reports · 2017Article
- Blue light therapy improves circadian dysfunction as well as motor symptoms in two mouse models of Huntington's disease.Neurobiology of sleep and circadian rhythms · 2017Article
- Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice.Nature biotechnology · 2016Article
- Human glia can both induce and rescue aspects of disease phenotype in Huntington disease.Nature communications · 2016Article
- High-throughput analysis of behavior for drug discovery.European journal of pharmacology · 2015Review
- Is Dysregulation of the HPA-Axis a Core Pathophysiology Mediating Co-Morbid Depression in Neurodegenerative Diseases?Frontiers in psychiatry · 2015Review
- Circadian dysfunction in response to in vivo treatment with the mitochondrial toxin 3-nitropropionic acid.ASN neuro · 2014Article
- How to fix a broken clock.Trends in pharmacological sciences · 2013Article
- Increased Body Weight of the BAC HD Transgenic Mouse Model of Huntington's Disease Accounts for Some but Not All of the Observed HD-like Motor Deficits.PLoS currents · 2013Article
- The Q175 mouse model of Huntington's disease shows gene dosage- and age-related decline in circadian rhythms of activity and sleep.PloS one · 2013Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Huntington's disease (HD) is a progressive neurodegenerative disease marked by psychiatric and motor problems. Recently, these findings have been extended to deficits in sleep and circadian function that can be observed in HD patients and in HD mouse models, with abnormal sleep patterns correlating with symptom severity in patients. Here, we studied the behavior of the BAC HD mouse model using an 24/7 automated system; the results indicate significant lengthening of the circadian period in the mutant mice. These results reinforce previous findings in HD models and symptomatic HD patients, indicating that circadian dysfunction is a core feature of HD.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.