ArticleOptics letters2011
In vivo integrated photoacoustic and confocal microscopy of hemoglobin oxygen saturation and oxygen partial pressure.
Article in Optics letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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Who cites it
56 citing papers in PubMed, 123 citations in OpenAlex.
- Photoacoustic Imaging Reveals Early Hemodynamic Changes in Diabetic Nephropathy: Hemoglobin Rise Prior to Oxygen Saturation Drop.Journal of biophotonics · 2026Article
- Understanding Immune Cell Adaptation to Tumor Hypoxia for Maximized Therapeutic Efficacy of Immunotherapy: Biology and Non-invasive Imaging Application.Cancer research and treatment · 2026Review
- Resting-state brain network alterations in spinal cord injury patients: an fNIRS study.Frontiers in human neuroscience · 2026Article
- A comprehensive review of high-performance photoacoustic microscopy systems.Photoacoustics · 2025Review
- Integrated two-photon and optoacoustic microscopy for functional neuroimaging.Scientific reports · 2025Article
- Simultaneous head-mounted imaging of neural and hemodynamic activities at high spatiotemporal resolution in freely behaving mice.Science advances · 2025Article
- Multimodal optoacoustic imaging: methods and contrast materials.Chemical Society reviews · 2024Review
- Relief of tumor hypoxia using a nanoenzyme amplifies NIR-II photoacoustic-guided photothermal therapy.Biomedical optics express · 2024Article
- Photoacoustic imaging to monitor outcomes during hyperbaric oxygen therapy: validation in a small cohort and case study in a bilateral chronic ischemic wound.Biomedical optics express · 2022Article
- Photoacoustic image-guided biomimetic nanoparticles targeting rheumatoid arthritis.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Expression and Variations inGenes · 2022Article
- Two-step proximal gradient descent algorithm for photoacoustic signal unmixing.Photoacoustics · 2022Article
- Sweep Pulse Excitation Method for Enhancing Photoacoustic Elastic Waves at Different Laser Irradiation Parameters.Sensors (Basel, Switzerland) · 2022Article
- Functional photoacoustic microscopy of hemodynamics: a review.Biomedical engineering letters · 2022Review
- Deep learning enabled real-time photoacoustic tomography system via single data acquisition channel.Photoacoustics · 2021Article
- Listening to tissues with new light: recent technological advances in photoacoustic imaging.Journal of optics (2010) · 2019Article
- Development of a blood oxygenation phantom for photoacoustic tomography combined with online pO2 detection and flow spectrometry.Journal of biomedical optics · 2019Article
- Article
- Photoacoustic-based oxygen saturation assessment of murine femoral bone marrow in a preclinical model of leukemia.Photoacoustics · 2019Article
- The integrated high-resolution reflection-mode photoacoustic and fluorescence confocal microscopy.Photoacoustics · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We developed dual-modality microscope integrating photoacoustic microscopy (PAM) and fluorescence confocal microscopy (FCM) to noninvasively image hemoglobin oxygen saturation (sO₂) and oxygen partial pressure (pO₂) in vivo in single blood vessels with high spatial resolution. While PAM measures sO₂ by imaging hemoglobin optical absorption at two wavelengths, FCM quantifies pO₂ using phosphorescence quenching. The variations of sO₂ and pO₂ values in multiple orders of vessel branches under hyperoxic (100% oxygen) and normoxic (21% oxygen) conditions correlate well with the oxygen-hemoglobin dissociation curve. In addition, the total concentration of hemoglobin is imaged by PAM at an isosbestic wavelength.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.