Evidence map›Paper›PMID 21478900›Full record

ReviewNature reviews. Microbiology2011

Termination and antitermination: RNA polymerase runs a stop sign.

Thomas J Santangelo, Irina Artsimovitch

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

113 citing papers in PubMed, 205 citations in OpenAlex.

  1. Article
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  3. mBio · 2025
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  10. Rli51 Attenuates Transcription of theInternational journal of molecular sciences · 2024
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  11. Review
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53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Thomas J SantangeloDepartment of Microbiology and The RNA Group, The Ohio State University, Columbus, Ohio 43210, USA.
Irina Artsimovitch
The Ohio State University · US

Funding

Mechnanism of transcript elongation control by RfaHR01GM067153 · NIGMS · OHIO STATE UNIVERSITY · PI IRINA ARTSIMOVITCH · 2003 to 2026
$8.0M
Archaeal Transcription TerminationF32GM073336 · NIGMS · OHIO STATE UNIVERSITY · PI SANTANGELO, THOMAS JAMES · 2005 to 2007
$151k
NIGMS NIH HHS F32 GM073336NIGMS NIH HHS F32-GM073336NIGMS NIH HHS GM67153NIGMS NIH HHS R01 GM067153
6 · The paper itself

Abstract

Termination signals induce rapid and irreversible dissociation of the nascent transcript from RNA polymerase. Terminators at the end of genes prevent unintended transcription into the downstream genes, whereas terminators in the upstream regulatory leader regions adjust expression of the structural genes in response to metabolic and environmental signals. Premature termination within an operon leads to potentially deleterious defects in the expression of the downstream genes, but also provides an important surveillance mechanism. This Review discusses the actions of bacterial and phage antiterminators that allow RNA polymerase to override a terminator when the circumstances demand it.

Indexed as

Transcription, GeneticBacteriaBacterial ProteinsBacteriophagesDNA-Directed RNA PolymerasesRibosomesRNA-Binding ProteinsRNA, TransferTerminator Regions, Geneticantiterminator proteins, BacteriaBacterial ProteinsDNA-Directed RNA PolymerasesRNA-Binding ProteinsRNA, Transfer

Identifiers

PMID21478900
PMCPMC3125153
OpenAlexW1998614048

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.