ArticleNature cell biology2011
Auxin triggers a genetic switch.
Article in Nature cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
57 citing papers in PubMed, 122 citations in OpenAlex.
- Mutational analyses of an instability domain reveal its conserved role in the regulation of class-B ARF levels inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- MONOPTEROS isoform MP11ir plays a role during somatic embryogenesis in Arabidopsis thaliana.Plant physiology · 2025Article
- Mechanisms of auxin action in plant growth and development.Nature reviews. Molecular cell biology · 2025Review
- Game of thrones among AUXIN RESPONSE FACTORs-over 30 years of MONOPTEROS research.Journal of experimental botany · 2023Review
- Cytokinins - regulators ofFrontiers in plant science · 2023Review
- Molecular Mechanisms of Diverse Auxin Responses during Plant Growth and Development.International journal of molecular sciences · 2022Review
- Review
- Transcriptome mining of hormonal and floral integrators in the leafless flowers of three cymbidium orchids.Frontiers in plant science · 2022Article
- Genetic insights into the regulatory pathways for continuous flowering in a unique orchid Arundina graminifolia.BMC plant biology · 2021Article
- Auxin Does the SAMba: Auxin Signaling in the Shoot Apical Meristem.Cold Spring Harbor perspectives in biology · 2021Review
- Stage Specificity, the Dynamic Regulators and the Unique OrchidInternational journal of molecular sciences · 2021Article
- Control of vein-forming, striped gene expression by auxin signaling.BMC biology · 2021Article
- Of Cells, Strands, and Networks: Auxin and the Patterned Formation of the Vascular System.Cold Spring Harbor perspectives in biology · 2021Review
- Zygotic Embryogenesis in Flowering Plants.Methods in molecular biology (Clifton, N.J.) · 2021Review
- Genome-wide analysis of lncRNA and mRNA expression and endogenous hormone regulation during tension wood formation in Catalpa bungei.BMC genomics · 2020Article
- Letter to the Editor: Author Response-The Role of Auxin in Late Stamen Development.Plant & cell physiology · 2020Article
- The CEP5 Peptide Promotes Abiotic Stress Tolerance, As Revealed by Quantitative Proteomics, and Attenuates the AUX/IAA Equilibrium inMolecular & cellular proteomics : MCP · 2020Article
- AtNSE1 and AtNSE3 are required for embryo pattern formation and maintenance of cell viability during Arabidopsis embryogenesis.Journal of experimental botany · 2019Article
- Identification of Auxin Response Factor-Encoding Genes Expressed in Distinct Phases of Leaf Vein Development and with Overlapping Functions in Leaf Formation.Plants (Basel, Switzerland) · 2019Article
- Auxin regulates endosperm cellularization inGenes & development · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell specification in development requires robust gene-regulatory responses to transient signals. In plants, the small signalling molecule auxin has been implicated in diverse developmental processes. Auxin promotes the degradation of AUXIN/INDOLE-3-ACETIC ACID (AUX/IAA) inhibitors that prevent AUXIN RESPONSE FACTOR (ARF) transcription factors from regulating their target genes. However, the precise role of auxin in patterning has remained unclear, the view of auxin acting as a morphogen is controversial and the transcriptional control of the ARF genes themselves is barely explored. Here, we demonstrate by experimental and computational analyses that the Arabidopsis ARF protein MONOPTEROS (MP) controls its own expression and the expression of its AUX/IAA inhibitor BODENLOS (BDL), with auxin acting as a threshold-specific trigger by promoting the degradation of the inhibitor. Our results suggest a general mechanism for how the transient accumulation of auxin activates self-sustaining or hysteretic feedback systems of interacting auxin-response proteins that, similarly to other genetic switches, result in unequivocal developmental responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.