ArticleJournal of bacteriology2011
The genome of Erysipelothrix rhusiopathiae, the causative agent of swine erysipelas, reveals new insights into the evolution of firmicutes and the organism's intracellular adaptations.
Article in Journal of bacteriology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 96 citations in OpenAlex.
- An ancient Erysipelothrix rhusiopathiae genome recovered from 1400-year-old human remains in the Northern Caucasus.Scientific reports · 2026Article
- Prophage φEr670 and Genomic Island GI_Er147 as Carriers of Resistance Genes inInternational journal of molecular sciences · 2025Article
- Comparative Phenotypic and Genotypic Analysis ofAntibiotics (Basel, Switzerland) · 2025Article
- Serotypes, Antimicrobial Susceptibility, and Potential Mechanisms of Resistance Gene Transfer inInternational journal of molecular sciences · 2024Article
- Genomic characterization and virulence gene profiling of Erysipelothrix rhusiopathiae isolated from widespread muskox mortalities in the Canadian Arctic Archipelago.BMC genomics · 2024Article
- Clinical polymorphism of zoonotic cutaneous leishmaniasis: combination of the clinical and the parasitological diagnosis.Parasitology research · 2024Article
- Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024Article
- Integrative and Conjugative Elements and Prophage DNA as Carriers of Resistance Genes inInternational journal of molecular sciences · 2024Article
- Phenotypic and Genotypic Characterization of a Highly VirulentTransboundary and emerging diseases · 2024Article
- Multiple independent losses of sporulation and peptidoglycan in theMicrobial genomics · 2024Article
- Serotypes, Antibiotic Susceptibility, Genotypic Virulence Profiles and SpaA Variants ofPathogens (Basel, Switzerland) · 2023Article
- Population Structure and Genomic Characteristics of AustralianMicroorganisms · 2023Article
- Rational Design of Live-Attenuated Vaccines against Genome-Reduced Pathogens.Microbiology spectrum · 2022Article
- Genome Sequence ofMicrobiology resource announcements · 2022Article
- The Swine Erysipelas Vaccine SER-ME Effectively Protects Pigs against Challenge with theVeterinary sciences · 2022Article
- The C-Terminal Repeat Units of SpaA Mediate Adhesion ofBiology · 2022Article
- A PCR assay to specifically detect serovar 1a strains of Erysipelothrix rhusiopathiae and differentiate them from serovar 2 strains possessing an intact ERH_1440 gene.The Journal of veterinary medical science · 2022Article
- HumanFrontiers in cellular and infection microbiology · 2022Article
- Pathological and Genomic Findings ofFrontiers in veterinary science · 2022Article
- Characterization of the first cultured free-living representative of Candidatus Izemoplasma uncovers its unique biology.The ISME journal · 2021Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Erysipelothrix rhusiopathiae is a Gram-positive bacterium that represents a new class, Erysipelotrichia, in the phylum Firmicutes. The organism is a facultative intracellular pathogen that causes swine erysipelas, as well as a variety of diseases in many animals. Here, we report the first complete genome sequence analysis of a member of the class Erysipelotrichia. The E. rhusiopathiae genome (1,787,941 bp) is one of the smallest genomes in the phylum Firmicutes. Phylogenetic analyses based on the 16S rRNA gene and 31 universal protein families suggest that E. rhusiopathiae is phylogenetically close to Mollicutes, which comprises Mycoplasma species. Genome analyses show that the overall features of the E. rhusiopathiae genome are similar to those of other Gram-positive bacteria; it possesses a complete set of peptidoglycan biosynthesis genes, two-component regulatory systems, and various cell wall-associated virulence factors, including a capsule and adhesins. However, it lacks many orthologous genes for the biosynthesis of wall teichoic acids (WTA) and lipoteichoic acids (LTA) and the dltABCD operon, which is responsible for d-alanine incorporation into WTA and LTA, suggesting that the organism has an atypical cell wall. In addition, like Mollicutes, its genome shows a complete loss of fatty acid biosynthesis pathways and lacks the genes for the biosynthesis of many amino acids, cofactors, and vitamins, indicating reductive genome evolution. The genome encodes nine antioxidant factors and nine phospholipases, which facilitate intracellular survival in phagocytes. Thus, the E. rhusiopathiae genome represents evolutionary traits of both Firmicutes and Mollicutes and provides new insights into its evolutionary adaptations for intracellular survival.
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