ArticleJournal of bacteriology2011
ATP requirement for acidic resistance in Escherichia coli.
Article in Journal of bacteriology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Quantitative transcriptomic and metabolic analyses reveal the roles of RpoS and Crp in the acid resistance system 1 inMicrobiology spectrum · 2026Article
- FhlA-mediated regulation of proton transport and energy transduction in Escherichia coli at acidic pH.PloS one · 2026Article
- FScientific reports · 2025Article
- Proton motive force generated by microbial rhodopsin promotes extracellular electron transfer.Synthetic and systems biotechnology · 2025Article
- Chromosomal genes modulating fosfomycin susceptibility in uropathogenicAntimicrobial agents and chemotherapy · 2025Article
- Dissecting Metabolic Functions and Sugar Transporters Using Genome and Transportome of ProbioticGenes · 2025Article
- Can antimicrobial blue light contribute to resistance development? Genome-wide analysis revealed aBL-protective genes inMicrobiology spectrum · 2024Article
- Expression of Human Uncoupling Protein-1 in Escherichia coli Decreases its Survival Under Extremely Acidic Conditions.Current microbiology · 2022Article
- Insights into Emergence of Antibiotic Resistance in Acid-Adapted EnterohaemorrhagicAntibiotics (Basel, Switzerland) · 2021Review
- Comparative Genome-Wide Transcriptome Analysis ofFrontiers in microbiology · 2021Article
- Microbial interaction between the succinate-utilizing bacterium Phascolarctobacterium faecium and the gut commensal Bacteroides thetaiotaomicron.MicrobiologyOpen · 2020Article
- Article
- The soluble transhydrogenase UdhA affecting the glutamate-dependent acid resistance system ofBiology open · 2018Article
- Acid-regulated gene expression of Helicobacter pylori: Insight into acid protection and gastric colonization.Helicobacter · 2018Article
- Article
- Development of a 3-hydroxypropionate resistant Escherichia coli strain.Bioengineered · 2016Article
- Protein plasticity underlines activation and function of ATP-independent chaperones.Frontiers in molecular biosciences · 2015Review
- Performance study of chromium (VI) removal in presence of phenol in a continuous packed bed reactor by Escherichia coli isolated from East Calcutta Wetlands.BioMed research international · 2013Article
- Respiration and the F₁Fo-ATPase enhance survival under acidic conditions in Escherichia coli.PloS one · 2012Article
- The Role of Efflux Pumps and Environmental pH in Bacterial Multidrug Resistance.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ATP participates in many cellular metabolic processes as a major substrate to supply energy. Many systems for acidic resistance (AR) under extremely acidic conditions have been reported, but the role of ATP has not been examined. To clarify whether or not ATP is necessary for the AR in Escherichia coli, the AR of mutants deficient in genes for ATP biosynthesis was investigated in this study. The deletion of purA or purB, each of which encodes enzymes to produce AMP from inosinate (IMP), markedly decreased the AR. The content of ATP in these mutants decreased rapidly at pH 2.5 compared to that of the wild type. The AR was again decreased significantly by the mutation of adk, which encoded an enzyme to produce ADP from AMP. The DNA damage in the purA and purB mutants was higher than that in the wild type. These results demonstrated that metabolic processes that require ATP participate in survival under extremely acidic conditions, and that one such system is the ATP-dependent DNA repair system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.