ArticleNucleic acids research2011
Long-range chromatin interactions at the mouse Igf2/H19 locus reveal a novel paternally expressed long non-coding RNA.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
- The superpowers of imprinting control regions.Genome research · 2026Review
- Long noncoding RNAs: glycolysis regulators in gynaecologic cancers.Cancer cell international · 2023Review
- LncRNA MBNL1-AS1 represses gastric cancer progression via the TGF-β pathway by modulating miR-424-5p/Smad7 axis.Bioengineered · 2022Article
- TET3 controls the expression of the H3K27me3 demethylase Kdm6b during neural commitment.Cellular and molecular life sciences : CMLS · 2021Article
- ASHIC: hierarchical Bayesian modeling of diploid chromatin contacts and structures.Nucleic acids research · 2020Article
- Long non-coding RNAs in ovarian cancer: expression profile and functional spectrum.RNA biology · 2020Review
- Review
- CTCF modulates allele-specific sub-TAD organization and imprinted gene activity at the mouse Dlk1-Dio3 and Igf2-H19 domains.Genome biology · 2019Article
- Long non-coding RNA XIST promotes osteoporosis through inhibiting bone marrow mesenchymal stem cell differentiation.Experimental and therapeutic medicine · 2019Article
- High-salt-recovered sequences are associated with the active chromosomal compartment and with large ribonucleoprotein complexes including nuclear bodies.Genome research · 2018Article
- PM20D1 is a quantitative trait locus associated with Alzheimer's disease.Nature medicine · 2018Article
- Intergenic and intronic DNA hypomethylated regions as putative regulators of imprinted domains.Epigenomics · 2018Article
- The Effect of Vitrification on Expression and Histone Marks of Igf2 and Oct4 in Blastocysts Cultured from Two-Cell Mouse Embryos.Cell journal · 2018Article
- Review
- Pre-neoplastic epigenetic disruption of transcriptional enhancers in chronic inflammation.Oncotarget · 2016Article
- Distinct polymer physics principles govern chromatin dynamics in mouse and Drosophila topological domains.BMC genomics · 2015Article
- Review
- The role of long non-coding RNAs in genome formatting and expression.Frontiers in genetics · 2015Review
- A novel virus-inducible enhancer of the interferon-β gene with tightly linked promoter and enhancer activities.Nucleic acids research · 2014Article
- A view through a chromatin loop: insights into the ecdysone activation of early genes in Drosophila.Nucleic acids research · 2014Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parental genomic imprinting at the Igf2/H19 locus is controlled by a methylation-sensitive CTCF insulator that prevents the access of downstream enhancers to the Igf2 gene on the maternal chromosome. However, on the paternal chromosome, it remains unclear whether long-range interactions with the enhancers are restricted to the Igf2 promoters or whether they encompass the entire gene body. Here, using the quantitative chromosome conformation capture assay, we show that, in the mouse liver, the endodermal enhancers have low contact frequencies with the Igf2 promoters but display, on the paternal chromosome, strong interactions with the intragenic differentially methylated regions 1 and 2. Interestingly, we found that enhancers also interact with a so-far poorly characterized intergenic region of the locus that produces a novel imprinted long non-coding transcript that we named the paternally expressed Igf2/H19 intergenic transcript (PIHit) RNA. PIHit is expressed exclusively from the paternal chromosome, contains a novel discrete differentially methylated region in a highly conserved sequence and, surprisingly, does not require an intact ICR/H19 gene region for its imprinting. Altogether, our data reveal a novel imprinted domain in the Igf2/H19 locus and lead us to propose a model for chromatin folding of this locus on the paternal chromosome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.