ArticleMalaria journal2011
Parasitostatic effect of maslinic acid. I. Growth arrest of Plasmodium falciparum intraerythrocytic stages.
Article in Malaria journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 44 citations in OpenAlex.
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- Antimalarial efficacy ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024Article
- Isolation and Characterization of NpCI, a New Metallocarboxypeptidase Inhibitor from the Marine SnailMarine drugs · 2023Article
- Investigation of Antiparasitic Activity of 10 European Tree Bark Extracts on Toxoplasma gondii and Bioguided Identification of Triterpenes inAntimicrobial agents and chemotherapy · 2022Article
- Human Group IIA Phospholipase AMolecules (Basel, Switzerland) · 2021Review
- Evaluation of in vivo anti-malarial potential of omidun obtained from fermented maize in Ibadan, Nigeria.Malaria journal · 2020Article
- Structural Insights Into KeyFrontiers in microbiology · 2019Review
- Maslinic acid promotes autophagy by disrupting the interaction between Bcl2 and Beclin1 in rat pheochromocytoma PC12 cells.Oncotarget · 2017Article
- Using a genome-scale metabolic network model to elucidate the mechanism of chloroquine action in Plasmodium falciparum.International journal for parasitology. Drugs and drug resistance · 2017Article
- In vitro inhibitory effects of plant-derived by-products against Cryptosporidium parvum.Parasite (Paris, France) · 2016Article
- In vivo curative and protective potential of orally administered 5-aminolevulinic acid plus ferrous ion against malaria.Antimicrobial agents and chemotherapy · 2015Article
- Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Maslinic acid, a natural phytoalexin-type triterpene from olives--a promising nutraceutical?Molecules (Basel, Switzerland) · 2014Review
- Parasitostatic effect of maslinic acid. II. Survival increase and immune protection in lethal Plasmodium yoelii-infected mice.Malaria journal · 2011Article
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6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNatural products have played an important role as leads for the development of new drugs against malaria. Recent studies have shown that maslinic acid (MA), a natural triterpene obtained from olive pomace, which displays multiple biological and antimicrobial activities, also exerts inhibitory effects on the development of some Apicomplexan, including Eimeria, Toxoplasma and Neospora. To ascertain if MA displays anti-malarial activity, the main objective of this study was to asses the effect of MA on Plasmodium falciparum-infected erythrocytes in vitro.
methodsSynchronized P. falciparum-infected erythrocyte cultures were incubated under different conditions with MA, and compared to chloroquine and atovaquone treated cultures. The effects on parasite growth were determined by monitoring the parasitaemia and the accumulation of the different infective stages visualized in thin blood smears.
resultsMA inhibits the growth of P. falciparum Dd2 and 3D7 strains in infected erythrocytes in, dose-dependent manner, leading to the accumulation of immature forms at IC50 concentrations, while higher doses produced non-viable parasite cells. MA-treated infected-erythrocyte cultures were compared to those treated with chloroquine or atovaquone, showing significant differences in the pattern of accumulation of parasitic stages. Transient MA treatment at different parasite stages showed that the compound targeted intra-erythrocytic processes from early-ring to schizont stage. These results indicate that MA has a parasitostatic effect, which does not inactivate permanently P. falciparum, as the removal of the compound allowed the infection to continue
conclusionsMA displays anti-malarial activity at multiple intraerythrocytic stages of the parasite and, depending on the dose and incubation time, behaves as a plasmodial parasitostatic compound. This novel parasitostatic effect appears to be unrelated to previous mechanisms proposed for current anti-malarial drugs, and may be relevant to uncover new prospective plasmodial targets and opens novel possibilities of therapies associated to host immune response.
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