ArticleTheoretical biology & medical modelling2011
A mathematical model of quorum sensing regulated EPS production in biofilm communities.
Article in Theoretical biology & medical modelling, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 138 citations in OpenAlex.
- Using stochastic cellular automata to model and define sufficient conditions for the survival of Enterococcus faecalis biofilms with the pCF10 plasmid under erythromycin treatment.PLoS computational biology · 2025Article
- Modeling the reactive oxygen species (ROS) wave in Chlamydomonas reinhardtii colonies.Free radical biology & medicine · 2024Article
- Unveiling bacterial communication with a MATLAB GUI implementing the diffusion-based quorum sensing model.Scientific reports · 2024Article
- Cooperation in bioluminescence: understanding the role of autoinducers by a stochastic random resistor model.The European physical journal. E, Soft matter · 2023Article
- Advancing understanding of microbial biofilms through machine learning-powered studies.Food science and biotechnology · 2023Review
- The Anti-Biofilm Activity and Mechanism of Apigenin-7-O-Glucoside AgainstInfection and drug resistance · 2023Article
- Quorum Sensing and Quorum Quenching with a Focus on Cariogenic and Periodontopathic Oral Biofilms.Microorganisms · 2022Review
- Mechanisms, Anti-Quorum-Sensing Actions, and Clinical Trials of Medicinal Plant Bioactive Compounds against Bacteria: A Comprehensive Review.Molecules (Basel, Switzerland) · 2022Review
- Emergent robustness of bacterial quorum sensing in fluid flow.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Beyond Risk: Bacterial Biofilms and Their Regulating Approaches.Frontiers in microbiology · 2020Review
- Challenges of biofilm control and utilization: lessons from mathematical modelling.Journal of the Royal Society, Interface · 2019Article
- Fly ash based robust biocatalyst generation: a sustainable strategy towards enhanced green biosurfactant production and waste utilization.RSC advances · 2019Article
- Bacteria Floc, but Do They Flock? Insights from Population Interaction Models of Quorum Sensing.mBio · 2019Article
- Therapeutic Microbiology: The Role ofNutrients · 2018Review
- Continuum and discrete approach in modeling biofilm development and structure: a review.Journal of mathematical biology · 2018Review
- Extracellular Polymeric Substance Production and Aggregated Bacteria Colonization Influence the Competition of Microbes in Biofilms.Frontiers in microbiology · 2017Article
- In Silico Evaluation of the Impacts of Quorum Sensing Inhibition (QSI) on Strain Competition and Development of QSI Resistance.Scientific reports · 2016Article
- Article
- Exploiting Quorum Sensing Interfering Strategies in Gram-Negative Bacteria for the Enhancement of Environmental Applications.Frontiers in microbiology · 2015Review
- Modeling the response of a biofilm to silver-based antimicrobial.Mathematical biosciences · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBiofilms are microbial communities encased in a layer of extracellular polymeric substances (EPS). The EPS matrix provides several functional purposes for the biofilm, such as protecting bacteria from environmental stresses, and providing mechanical stability. Quorum sensing is a cell-cell communication mechanism used by several bacterial taxa to coordinate gene expression and behaviour in groups, based on population densities. MODEL: We mathematically model quorum sensing and EPS production in a growing biofilm under various environmental conditions, to study how a developing biofilm impacts quorum sensing, and conversely, how a biofilm is affected by quorum sensing-regulated EPS production. We investigate circumstances when using quorum-sensing regulated EPS production is a beneficial strategy for biofilm cells.
resultsWe find that biofilms that use quorum sensing to induce increased EPS production do not obtain the high cell populations of low-EPS producers, but can rapidly increase their volume to parallel high-EPS producers. Quorum sensing-induced EPS production allows a biofilm to switch behaviours, from a colonization mode (with an optimized growth rate), to a protection mode.
conclusionsA biofilm will benefit from using quorum sensing-induced EPS production if bacteria cells have the objective of acquiring a thick, protective layer of EPS, or if they wish to clog their environment with biomass as a means of securing nutrient supply and outcompeting other colonies in the channel, of their own or a different species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.