ArticleBMC infectious diseases2011
Community-based cross-sectional survey of latent tuberculosis infection in Afar pastoralists, Ethiopia, using QuantiFERON-TB Gold In-Tube and tuberculin skin test.
Article in BMC infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Global prevalence of Mycobacterium bovis infections among human tuberculosis cases: Systematic review and meta-analysis.Zoonoses and public health · 2021Pooled it
- Prevalence of Latent Tuberculosis Infection in the Middle East and North Africa: A Systematic Review.Pulmonary medicine · 2021Pooled it
- The effect of maternal helminth infection on maternal and neonatal immune function and immunity to tuberculosis.PloS one · 2014Trial
- Post-release tuberculosis risk among formerly incarcerated populations in Lima Peru.Nature communications · 2026Article
- The Hidden Epidemic: Post-Release Tuberculosis Risk in Formerly Incarcerated Populations.Research square · 2025Article
- Detection ofThe Lancet. Microbe · 2021Observational
- Comparison of Interferon-Gamma Release Assay and Tuberculin Skin Test for the Screening of Latent Tuberculosis in Inflammatory Bowel Disease Patients: Indian Scenario.Tuberculosis research and treatment · 2021Article
- Tuberculin skin test positivity among HIV-infected alcohol drinkers on antiretrovirals in south-western Uganda.PloS one · 2020Article
- Does Isoniazid Preventive Therapy Provide Better Treatment Outcomes in HIV-Infected Individuals in Northern Ethiopia? A Retrospective Cohort Study.AIDS research and treatment · 2020Article
- Latent tuberculosis infection and associated risk factors among people living with HIV and apparently healthy blood donors at the University of Gondar referral hospital, Northwest Ethiopia.BMC research notes · 2019Article
- Sex differences in tuberculosis.Seminars in immunopathology · 2019Review
- Performance of the QuantiFERONThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2018Article
- Latent tuberculosis infection and associated risk indicators in pastoral communities in southern Ethiopia: a community based cross-sectional study.BMC public health · 2018Article
- Use of tuberculin skin test for assessment of immune recovery among previously malnourished children in Ethiopia.BMC research notes · 2017Article
- Prevalence and risk factors of latent tuberculosis infection in Africa: a systematic review and meta-analysis protocol.BMJ open · 2017Article
- Interferon-gamma release assay for the diagnosis of latent tuberculosis infection: A latent-class analysis.PloS one · 2017Article
- Prevalence of latent tuberculosis infection and predictive factors in an urban informal settlement in Johannesburg, South Africa: a cross-sectional study.BMC infectious diseases · 2016Article
- Detection of latent tuberculosis infection among migrant farmworkers along the US-Mexico border.BMC infectious diseases · 2016Article
- Prevalence and risk factors of latent Tuberculosis among adolescents in rural Eastern Uganda.African health sciences · 2015Article
- Current tuberculin reactivity of schoolchildren in the Central African Republic.BMC public health · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is little information concerning community-based prevalence of latent tuberculosis infection (LTBI) using T-cell based interferon-γ (IFN-γ) release assays (IGRAs), particularly in TB endemic settings. In this study, the prevalence of LTBI in the Afar pastoral community was assessed using QuantiFERON-TB Gold In-Tube (QFTGIT) and tuberculin skin tests (TST).
methodsA community-based cross-sectional survey of LTBI involving 652 apparently healthy adult pastoralists was undertaken in the pastoral community of Amibara District of the Afar Region between April and June 2010.
resultsThe prevalence of LTBI was estimated as 63.7% (363/570) using QFTGIT at the cut-off point recommended by the manufacturer (≥0.35 IU/ml IFN-γ), while it was 74.9% (427/570) using a cut-off point≥0.1 IU/ml IFN-γ. The QFTGIT-based prevalence of LTBI was not significantly associated with the gender or age of the study participants. However, the prevalence of LTBI was 31.2% (183/587) using TST at a cut-off point≥10 mm of skin indurations, and it was higher in males than females (36.8% vs. 23.5%, X2=11.76; p<0.001). There was poor agreement between the results of the tests (k=0.098, 95% CI, 0.08-0.13). However, there was a positive trend between QFTGIT and TST positivity (X2=96.76, P<0.001). Furthermore, individuals with skin indurations≥10 mm were 13.6 times more likely to have positive results using QFTGIT than individuals with skin indurations of 0 mm (adjusted OR=13.6; 95%CI, 7.5 to 24.7, p<0.001).
conclusionsThere is currently no agreed gold standard for diagnosis of LTBI. However, the higher prevalence of LTBI detected using QFTGIT rather than TST suggests that QFTGIT could be used for epidemiological studies concerning LTBI at the community level, even in a population unreactive to TST. Further studies of adults and children will be required to assess the effects of factors such as malnutrition, non-tuberculosis mycobacterial infections, HIV and parasitic infections on the performance of QFTGIT.
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