ArticleBritish journal of clinical pharmacology2011
The availability and age-appropriateness of medicines authorized for children in The Netherlands.
Article in British journal of clinical pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Guideline for the management of pediatric off-label use of drugs in China (2021).BMC pediatrics · 2022Guideline
- Acceptability of different oral formulations in infants and preschool children.Archives of disease in childhood · 2013Trial
- Age-Appropriateness of Oral Formulations Authorized for Pediatrics.Pharmaceutical research · 2026Article
- "We've managed to find our own path of how we do it": exploring parental perceptions of using age-inappropriate formulations at home-a qualitative study.Frontiers in pediatrics · 2026Article
- Extemporaneous Compounding, Pharmacy Preparations and Related Product Care in the Netherlands.Pharmaceutics · 2025Review
- Medicine use in children aged under 12 years-Population survey in Finland.Pharmacoepidemiology and drug safety · 2023Article
- Development of an Oral Liquid Formulation of Nicardipine Hydrochloride Compounded with Simple Excipients for the Treatment of Pediatric Hypertension.Pharmaceutics · 2023Article
- Development and evaluation of an assessment of the age-appropriateness/inappropriateness of formulations used in children.International journal of clinical pharmacy · 2022Article
- 3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?-A Scoping Review.Pharmaceutics · 2022Article
- Availability of age-appropriate paediatric formulations in the Netherlands: the need in daily clinical practice remains.European journal of hospital pharmacy : science and practice · 2021Article
- Assessing a Mass-Based Method for the Preparation of Low-Dosed Paediatric Capsules with Baclofen and Spironolactone.Pharmacy (Basel, Switzerland) · 2021Article
- Off-label use of medicines in neonates, infants, children, and adolescents: a joint policy statement by the European Academy of Paediatrics and the European society for Developmental Perinatal and Pediatric Pharmacology.European journal of pediatrics · 2020Article
- Suitability of new drugs registered in Brazil from 2003 to 2013 for pediatric age groups.Einstein (Sao Paulo, Brazil) · 2018Article
- A retrospective and observational analysis of harmful excipients in medicines for hospitalised neonates in Latvia.European journal of hospital pharmacy : science and practice · 2018Article
- Safe and effective pharmacotherapy in infants and preschool children: importance of formulation aspects.Archives of disease in childhood · 2016Review
- Off-label and unlicensed drug treatments in Neonatal Intensive Care Units: an Italian multicentre study.European journal of clinical pharmacology · 2016Article
- Toxic excipients in medications for neonates in Brazil.European journal of pediatrics · 2014Article
- Article
- Hospitalised neonates in Estonia commonly receive potentially harmful excipients.BMC pediatrics · 2012Article
- Availability of pediatric-evaluated formulations in Serbia.Indian journal of pharmacologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the number of medicines and active chemical entities that are authorized and commercially available for children in the Netherlands and to evaluate the age-appropriateness of the available paediatric medicines.
methodsThe availability of paediatric medicines and active chemical entities was studied with the help of a Dutch medicines database and the Summary of Product Characteristics. Medicines were categorized with respect to their route of administration, type of oral dosage form and therapeutic category. The age-appropriateness was assessed on three aspects: dose capability, suitability of the dosage form and inclusion of potentially harmful excipients.
resultsThree thousand five hundred and forty-two paediatric medicines containing 703 different active chemical entities were identified. This equalled half of all the medicines and chemical entities available for human use. The percentage of paediatric medicines increased with age and varied for the route of administration from 22% (dermal) to 81% (inhalation) and for the therapeutic category from 11% (uro-genital, sex hormones) to 89% (anti-parasites). The appropriateness of the paediatric medicines with respect to their authorization status, dose capability and dosage form increased with age from 27-88%. Fifty-two percent of all oral paediatric liquid formulations contained a potentially harmful excipient.
conclusionThis study confirms the limited availability of paediatric medicines for a broad range of therapeutic areas and shows that paediatric medicines may not be age-appropriate, even if authorized. While confirming the need for a legislative incentive, the results also provide baseline information for an estimation of the effect of the European Paediatric Regulation in the near future.
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