ArticleEnvironmental microbiology2011
Underestimated biodiversity as a major explanation for the perceived rich secondary metabolite capacity of the cyanobacterial genus Lyngbya.
Article in Environmental microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 76 citations in OpenAlex.
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- Nanosynthesis, phycochemical constituents, and pharmacological properties of cyanobacterium Oscillatoria sp.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Naturally Occurring Organohalogen Compounds-A Comprehensive Review.Progress in the chemistry of organic natural products · 2023Review
- Influence of Low Salt Concentration on Growth Behavior and General Biomass Composition inMarine drugs · 2020Article
- Characterization of Macroscopic Colony-Forming Filamentous Cyanobacteria from Okinawan Coasts as Potential Sources of Bioactive Compounds.Marine biotechnology (New York, N.Y.) · 2020Article
- Natural Products from Cyanobacteria: Focus on Beneficial Activities.Marine drugs · 2019Review
- Spatial Distribution of Collections Yielding Marine Natural Products.Journal of natural products · 2018Review
- Long-term effects of competition and environmental drivers on the growth of the endangered coralPeerJ · 2018Article
- Article
- Genome Sequence and Composition of a Tolyporphin-Producing Cyanobacterium-Microbial Community.Applied and environmental microbiology · 2017Article
- Article
- Prediction aided in vitro analysis of octa-decanoic acid from Cyanobacterium Lyngbya sp. as a proapoptotic factor in eliciting anti-inflammatory properties.Bioinformation · 2017Article
- New Cerebroside and Nucleoside Derivatives from a Red Sea Strain of the Marine Cyanobacterium Moorea producens.Molecules (Basel, Switzerland) · 2016Article
- Isolation and Synthesis of Laxaphycin B-Type Peptides: A Case Study and Clues to Their Biosynthesis.Marine drugs · 2015Article
- Draft Genome Assembly of Filamentous Brackish Cyanobacterium Limnoraphis robusta Strain CS-951.Genome announcements · 2015Article
- Microseiramide from the Freshwater CyanobacteriumPhytochemistry letters · 2015Article
- Targeted natural products discovery from marine cyanobacteria using combined phylogenetic and mass spectrometric evaluation.Journal of natural products · 2015Article
- Mass spectrometry of natural products: current, emerging and future technologies.Natural product reports · 2014Review
- Exploring bioactive properties of marine cyanobacteria isolated from the Portuguese coast: high potential as a source of anticancer compounds.Marine drugs · 2013Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Marine cyanobacteria are prolific producers of bioactive secondary metabolites responsible for harmful algal blooms as well as rich sources of promising biomedical lead compounds. The current study focused on obtaining a clearer understanding of the remarkable chemical richness of the cyanobacterial genus Lyngbya. Specimens of Lyngbya from various environmental habitats around Curaçao were analysed for their capacity to produce secondary metabolites by genetic screening of their biosynthetic pathways. The presence of biosynthetic pathways was compared with the production of corresponding metabolites by LC-ESI-MS² and MALDI-TOF-MS. The comparison of biosynthetic capacity and actual metabolite production revealed no evidence of genetic silencing in response to environmental conditions. On a cellular level, the metabolic origin of the detected metabolites was pinpointed to the cyanobacteria, rather than the sheath-associated heterotrophic bacteria, by MALDI-TOF-MS and multiple displacement amplification of single cells. Finally, the traditional morphology-based taxonomic identifications of these Lyngbya populations were combined with their phylogenetic relationships. As a result, polyphyly of morphologically similar cyanobacteria was identified as the major explanation for the perceived chemical richness of the genus Lyngbya, a result which further underscores the need to revise the taxonomy of this group of biomedically important cyanobacteria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.