ReviewPediatric nephrology (Berlin, Germany)2010
History, epidemiology and regional diversities of urolithiasis.
Review in Pediatric nephrology (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04071340 (The Natural History of Minimally Symptomatic Nonobstructing Calyceal Stones), which is not on this map. Cited by 173 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Natural History of Minimally Symptomatic Nonobstructing Calyceal Stones
Who cites it
173 citing papers in PubMed, 10 syntheses or guidelines pooled it, 457 citations in OpenAlex.
- Sterile water injections for analgesia in renal colic: a meta-analysis of level 1 evidence.World journal of urology · 2025Pooled it
- Prevalence and clinical patterns of urolithiasis in sub-saharan Africa: a systematic review and meta-analysis of observational studies.BMC nephrology · 2024Pooled it
- International Alliance of Urolithiasis (IAU) guidelines on the management of pediatric urolithiasis.Urolithiasis · 2024Guideline
- Super pulsed thulium fiber laser outcomes in retrograde intrarenal surgery for ureteral and renal stones: a systematic review and meta-analysis.BMC urology · 2023Pooled it
- Antiurolithic effects of medicinal plants: results of in vivo studies in rat models of calcium oxalate nephrolithiasis-a systematic review.Urolithiasis · 2021Pooled it
- Renal lithiasis and inflammatory bowel diseases, an update on pediatric population.Acta bio-medica : Atenei Parmensis · 2018Pooled it
- Pooled it
- Pooled it
- Comparison of laparoscopic stone surgery and percutaneous nephrolithotomy in the management of large upper urinary stones: a meta-analysis.Urolithiasis · 2016Pooled it
- Treatment effect, adherence, and safety of high fluid intake for the prevention of incident and recurrent kidney stones: a systematic review and meta-analysis.Journal of nephrology · 2016Pooled it
- Effect ofNutrients · 2020Trial
- Etiologic risk factors and vitamin D receptor gene polymorphisms in under one-year-old infants with urolithiasis.Urolithiasis · 2018Trial
- Effects of vitamin E ingestion on plasma and urinary risk factors for calcium oxalate urolithiasis in two population groups having different stone-risk profiles: evidence of different physiological handling mechanisms.Urological research · 2012Trial
- Extracorporeal shockwavelithotripsyWorld journal of critical care medicine · 2026Article
- Multifunctional Magnetic Droplet Robots for Urological Applications: From Drug Delivery to Stone Retrieval.Micromachines · 2026Article
- Epidemiology and risk factors of urolithiasis in the Turkestan region: a case-control study.Scientific reports · 2026Article
- Urolithiasis in Children-Clinical Picture, Pathogenesis, and Diagnostic Approach.Biomolecules · 2026Review
- Diversity in Clinical Characteristics and Composition of Urinary Stones in Different Regions of India and Comparison to Rest of the World.Annals of African medicine · 2026Review
- Article
- Trace element signatures and regional differences in kidney stones: insights from a high-prevalence region.Urolithiasis · 2025Article
113 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Archeological findings give profound evidence that humans have suffered from kidney and bladder stones for centuries. Bladder stones were more prevalent during older ages, but kidney stones became more prevalent during the past 100 years, at least in the more developed countries. Also, treatment options and conservative measures, as well as 'surgical' interventions have also been known for a long time. Our current preventive measures are definitively comparable to those of our predecessors. Stone removal, first lithotomy for bladder stones, followed by transurethral methods, was definitively painful and had severe side effects. Then, as now, the incidence of urolithiasis in a given population was dependent on the geographic area, racial distribution, socio-economic status and dietary habits. Changes in the latter factors during the past decades have affected the incidence and also the site and chemical composition of calculi, with calcium oxalate stones being now the most prevalent. Major differences in frequency of other constituents, particularly uric acid and struvite, reflect eating habits and infection risk factors specific to certain populations. Extensive epidemiological observations have emphasized the importance of nutritional factors in the pathogenesis of urolithiasis, and specific dietary advice is, nowadays, often the most appropriate for prevention and treatment of urolithiasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.