ArticlePituitary2012
Spontaneous recovery of bone mass after cure of endogenous hypercortisolism.
Article in Pituitary, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Clinical Practice Patterns in Bone Health Assessment and Management in Endogenous Cushing's Syndrome.Clinical endocrinology · 2026Article
- Screening for endogenous hypercortisolism in patients with osteoporosis and fractures: why, when and how.Journal of endocrinological investigation · 2025Review
- Review
- Review
- The efficacy of bisphosphonates for osteoporosis in young Cushing's disease patients with biochemical remission: a retrospective cohort study.Frontiers in endocrinology · 2024Article
- Osteoporotic vertebral compression fractures caused by Cushing's syndrome in young women: case report and literature review.BMC musculoskeletal disorders · 2023Review
- Musculoskeletal complications of Cushing syndrome.Reumatologia · 2023Review
- Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing's Disease.International journal of endocrinology · 2023Article
- Review
- Update on vertebral fractures in pituitary diseases: from research to clinical practice.Hormones (Athens, Greece) · 2021Review
- Assessment of non-traumatic vertebral fractures in Cushing's syndrome patients.Journal of endocrinological investigation · 2021Article
- Metastatic medullary thyroid carcinoma presenting as ectopic Cushing's syndrome.Endocrinology, diabetes & metabolism case reports · 2021Article
- Outcome and long-term follow-up of adrenal lesions in multiple endocrine neoplasia type 1.Archives of endocrinology and metabolism · 2019Article
- Lower extremity insufficiency fractures: an underappreciated manifestation of endogenous Cushing's syndrome.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Clinical and biochemical manifestations of Cushing's.Pituitary · 2015Review
- Fracture risk assessment before and after resolution of endogenous hypercortisolism: is the FRAX® algorithm useful?Journal of endocrinological investigation · 2014Article
- Treatment of skeletal impairment in patients with endogenous hypercortisolism: when and how?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
- Advances in the epidemiology, pathogenesis, and management of Cushing's syndrome complications.Journal of endocrinological investigation · 2012Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with Cushing's syndrome (CS) develop osteopenia-osteoporosis. The present study evaluates the recovery of bone mass within 2 years after remission of hypercortisolism and in long term follow up, an issue rarely addressed. Twenty patients (6M, 14F, 3 post-menopausal, 15-64 years old), 15 with Cushing's disease, 2 with ectopic ACTH syndrome, 3 with ACTH-independent CS were studied. BMD, T and Z scores at lumbar spine and proximal femur were assessed by dual-energy X-ray absorptiometry before and 7-33 months after treatment of hypercortisolism. Five patients were treated with bisphosphonates. Four patients had hypogonadism and 4 GH-deficiency. At baseline all patients showed osteopenia/osteoporosis and the spine appeared more damaged than the femur; femur BMD was positively related with body mass index (BMI). No correlations were observed between spine and femur bone parameters and duration of disease or severity of hypercortisolism. Bone parameters did not differ in patients with or without GH or other pituitary deficiencies. After cure of hypercortisolism a significant improvement in spine BMD, Z and T scores and in femur Z and T scores was observed with normalization in 3 patients; there was no significant difference in percent improvement between femur and spine. The increase in bone parameters at spine and femur was independent from values at baseline. The percent increase in spine T and Z scores was positively related with time elapsed since cure. Bisphosphonates did not influence the recovery of bone mineralization. In long term follow up, after a median period of 7 years a further improvement in bone density was observed in 100% of patients at spine and in 9/11 at femur, although 8/11 patients still had femoral and/or vertebral T score in the range of osteopenia/osteoporosis. Spontaneous improvement of osteoporosis after cure of hypercortisolism occurs both at spine and femur, is independent from basal conditions and not affected by bisphosphonates. The improvement at spine depends on time since cure.
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