SynthesisStem cell reviews and reports2011
Stem cell tracking in human trials: a meta-regression.
Synthesis in Stem cell reviews and reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Stem cell therapy for ischemic stroke: neuroimaging approaches and evidence from a systematic review.Frontiers in neurologyPooled it
- Cell therapy for stroke and spinal cord injury in clinical trials.Stem cells translational medicine · 2026Review
- Injectable collagen scaffold with human umbilical cord-derived mesenchymal stem cells promotes functional recovery in patients with spontaneous intracerebral hemorrhage: phase I clinical trial.Neural regeneration research · 2023Article
- Stem Cell Therapy for Acute/Subacute Ischemic Stroke with a Focus on Intraarterial Stem Cell Transplantation: From Basic Research to Clinical Trials.Bioengineering (Basel, Switzerland) · 2022Review
- Multi-modal imaging probe for assessing the efficiency of stem cell delivery to orthotopic breast tumours.Nanoscale · 2020Article
- Multicolor spectral photon counting CT monitors and quantifies therapeutic cells and their encapsulating scaffold in a model of brain damage.Nanotheranostics · 2020Article
- Motoric Recovery After Transplantation of Bone Marrow Derived Mesenchymal Stem Cells in Chronic Spinal Cord Injury: A Case Report.The American journal of case reports · 2019Article
- Hyaluronan-Based Grafting Strategies for Liver Stem Cell Therapy and Tracking Methods.Stem cells international · 2019Review
- Stem Cell Tracing Through MR Molecular Imaging.Tissue engineering and regenerative medicine · 2018Review
- Monocyte alterations in rheumatoid arthritis are dominated by preterm release from bone marrow and prominent triggering in the joint.Annals of the rheumatic diseases · 2018Article
- Article
- Accumulation and Toxicity of Superparamagnetic Iron Oxide Nanoparticles in Cells and Experimental Animals.International journal of molecular sciences · 2016Article
- Dynamic In Vivo SPECT Imaging of Neural Stem Cells Functionalized with Radiolabeled Nanoparticles for Tracking of Glioblastoma.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2016Article
- Concise review: workshop review: understanding and assessing the risks of stem cell-based therapies.Stem cells translational medicine · 2015Review
- Intra-Arterial Immunoselected CD34+ Stem Cells for Acute Ischemic Stroke.Stem cells translational medicine · 2014Article
- Detection of homing-in of stem cells labeled with technetium-99m hexamethylpropyleneamine oxime in infarcted myocardium after intracoronary injection.Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India · 2014Article
- Magnetic resonance imaging of transplanted stem cell fate in stroke.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Review
- In vivo tracking techniques for cellular regeneration, replacement, and redirection.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2012Review
- Personalized nanomedicine advancements for stem cell tracking.Advanced drug delivery reviews · 2012Review
- Stem cell therapy for the spinal cord.Stem cell research & therapy · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The potential effectiveness of cell therapies is dependent upon homing of transplanted cells to relevant target organs. In this study we firstly characterise the range of methods employed in all human therapeutic-cell studies published to date investigated with cell-tracking. Secondly, we determine factors that predict target-organ cell uptake efficiency by meta-regression. Following a comprehensive literature search, we identified 19 relevant trials, representing 145 patients over the following 7 diseases: myocardial infarction; Chagasic cardiomyopathy; ischemic stroke; traumatic injury of brain or spinal cord; diabetes and cirrhosis. Cell-labelling strategies employed were: 18-fluorodeoxyglucose-PET, 111-indium-SPECT; 99-technetium-SPECT, and iron oxide-MRI. The following methodological parameters were extracted: label type; label dose; labelling efficiency; stability; cell dose; percentage labelled cells; disease type and chronicity; cell purity; cell type; and cell uptake efficiency. Meta-regression techniques were used to identify predictors of cell-labelling efficiency; viability and cell uptake efficiency. These analyses found that labelling efficiency is proportionate to cell dose, while cell viability is lowest with indium and long label incubation times. Uptake efficiency of cells is predicted by stem cell purity (positive association) and cell infusion number (negative association), although these two variables are themselves strongly negatively correlated between studies. In summary the methodological factors associated with enhanced therapeutic-cell homing from both our own analysis, and within-trial comparisons, are: acute (versus chronic) disease, selective stem cells (versus unselected cells), and intra-arterial (versus intravenous) delivery. However, future trials need to keep cell doses and imaging times constant so as to enable meaningful comparisons in uptake efficiency.
Indexed as
Identifiers
21475954What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.