ArticleJournal of cachexia, sarcopenia and muscle2010
Systemic zinc redistribution and dyshomeostasis in cancer cachexia.
Article in Journal of cachexia, sarcopenia and muscle, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Review
- Association of COVID-19 mortality with serum selenium, zinc and copper: Six observational studies across Europe.Frontiers in immunology · 2022Observational
- Targeting the JAK2/STAT3 Pathway-Can We Compare It to the Two Faces of the God Janus?International journal of molecular sciences · 2020Review
- Defining a new model of interdisciplinary cancer cachexia care in regional Victoria, Australia.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Observational
- Review
- The acute phase serum zinc concentration is a reliable biomarker for predicting the functional outcome after spinal cord injury.EBioMedicine · 2019Article
- Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle.Nature medicine · 2018Article
- Potential Coagulation Factor-Driven Pro-Inflammatory Responses in Ovarian Cancer Tissues Associated with Insufficient O₂ and Plasma Supply.International journal of molecular sciences · 2017Review
- Pathophysiology of anorexia in the cancer cachexia syndrome.Journal of cachexia, sarcopenia and muscle · 2015Review
- Genetic basis of interindividual susceptibility to cancer cachexia: selection of potential candidate gene polymorphisms for association studies.Journal of genetics · 2014Review
- Highlights of mechanistic and therapeutic cachexia and sarcopenia research 2010 to 2012 and their relevance for cardiology.Archives of medical science : AMS · 2013Review
- Mammalian metallothionein in toxicology, cancer, and cancer chemotherapy.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2011Review
- Critical diaphragm failure in sudden infant death syndrome.Upsala journal of medical sciences · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cachexia affects up to two thirds of all cancer patients and is a significant cause of morbidity and mortality. It is a complex metabolic syndrome associated with the underlying illness and characterized by loss of skeletal muscle tissue with or without loss of fat mass. Cachexia's other prominent clinical symptoms include anorexia, systemic inflammation, pediatric growth failure, and hypogonadism. The relationship between the symptoms of cancer cachexia and the underlying illness is unclear, and there is an urgent need for a better understanding of the pathophysiology of this syndrome. Normal Zn metabolism is often disrupted in cancer patients, but the possible effects of systemic Zn dyshomeostasis in cachexia have not been investigated. We propose that the acute phase response can mediate Zn redistribution and accumulation in skeletal muscle tissue and contribute to the activation of the ubiquitin-proteasome pathway that regulates protein catabolism. This chronic redistribution deprives Zn from other tissues and organs and compromises critical physiological functions in the body. The cardinal symptoms of Zn deficiency are anorexia, systemic inflammation, growth failure in children, and hypogonadism. These symptoms also prominently characterize cancer cachexia suggesting that the role of systemic Zn dyshomeostasis in cachexia should be investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.