ArticleJournal of cachexia, sarcopenia and muscle2010
Cancer-related fatigue: the impact of skeletal muscle mass and strength in patients with advanced cancer.
Article in Journal of cachexia, sarcopenia and muscle, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05156424 (A Comparison of Aerobic and Resistance Exercise for Counteracting the Adverse Effects of Androgen Deprivation Therapy in Men With Prostate Cancer), which is not on this map. Cited by 94 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Comparison of Aerobic and Resistance Exercise for Counteracting the Adverse Effects of Androgen Deprivation Therapy in Men With Prostate Cancer
Who cites it
94 citing papers in PubMed, 3 syntheses or guidelines pooled it, 177 citations in OpenAlex.
- Exercise and Nutrition Interventions in Patients with Head and Neck Cancer during Curative Treatment: A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- The Effect of Nutrition Therapy and Exercise on Cancer-Related Fatigue and Quality of Life in Men with Prostate Cancer: A Systematic Review.Nutrients · 2017Pooled it
- The assessment and impact of sarcopenia in lung cancer: a systematic literature review.BMJ open · 2014Pooled it
- Muscle strength in breast cancer patients receiving different treatment regimes.Journal of cachexia, sarcopenia and muscle · 2017Trial
- Effects of exercise training on exercise capacity in patients with non-small cell lung cancer receiving targeted therapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2012Trial
- Article
- Multiple organs exhibit exacerbated cachexia in male mice with colon cancer than females.Journal of advanced research · 2026Article
- Sarcopenia in Oncological Patients Diagnostics, Screening, and Impact on Quality of Life, Fatigue, Handgrip Strength, and Physical Activity (Sarco-Detect Study).Cancer medicine · 2026Article
- Separating anorexia -dependent and -independent effects in cancer cachexia.bioRxiv : the preprint server for biology · 2026Article
- Nutritional pathways from treatment to management of sarcopenia in patients with gastric cancer: a narrative review.Korean journal of family medicine · 2026Review
- Towards Rapid Bedside Detection of Sarcopenia in Cancer Patients: The Role of Rectus Femoris Muscle Ultrasonography-A Prospective Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2026Article
- Survivorship Issues in Older Adults with Breast Cancer.Current breast cancer reports · 2025Article
- Assessing Head and Neck Cancer-Related Lymphoedema Using Indocyanine Green Lymphography-A Pilot Study.Head & neck · 2025Article
- Rehabilitation intervention to prevent adverse events related to ADT in patients with metastatic prostate cancer.Future science OA · 2025Article
- Baseline hypoalbuminemia enhances regorafenib-induced problematic fatigue development in real-world metastatic colorectal cancer treatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Tracking cancer-related fatigue during chemotherapy: Insights from a comparative cohort study of early breast cancer patients.International journal of cancer · 2025Article
- Skeletal Muscle-Specific Deletion of E3 Ligase Asb2 Enhances Muscle Mass and Strength.Journal of cachexia, sarcopenia and muscle · 2025Article
- Factors affecting pretransplant muscle strength in allogeneic stem cell transplant candidates prior transplantation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Relationship between physical function and quality of life based on treatment timing in patients with advanced lung cancer.Journal of physical therapy science · 2025Article
- Quality of life, fatigue, and muscle strength in women with breast cancer undergoing chemotherapy or hormonal therapy: a case-control study.Frontiers in oncology · 2025Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough exertional fatigue is directly and negatively related to skeletal muscle mass and strength, it is currently unknown if these variables are associated with cancer-related fatigue (CRF). Therefore, the purpose of this study was to determine if CRF is associated with measures of appendicular lean muscle mass and strength in advanced cancer patients (ACP). METHODS AND
resultsEighty-four patients (48 men, 36 women aged 61.6 ± 13.2 year) newly diagnosed (≤6 months) with inoperable (Stages III-IV) gastrointestinal or non-small cell lung cancer participated in this study. All patients completed the Brief Fatigue Inventory (BFI). Handgrip (HGS) and quadriceps (QS) strength were assessed using isometric and isokinetic dynamometry, respectively. Skeletal muscle mass index (SMMI) was calculated from the appendicular lean mass measured via dual-energy X-ray absorptiometry divided by body height squared. Univariate analysis showed BFI to be significantly associated with body mass index, weight loss, anemia, hypoalbuminemia, activity level, pain, depression, and sarcopenia along with SMMI, HGS, and QS. HGS (r = -0.34; p = 0.018), QS (r = -0.39; p = 0.024), and SMMI (r = -0.60; p < 0.001) were negatively correlated with BFI total scores in men but not in women. When adjusted for sex, age, diagnosis, survival, along with the above characteristics, multivariate analyses showed that BFI scores were negatively associated with HGS (B = -0.90; 95% CI -1.5:-0.3), QS (-0.2; -0.3:-0.01), and SMMI (-7.5; -13.0:-2.0). There was a significant sex × SMMI interaction (10.8; 1.2:20.5), where BFI decreased with increasing SMMI in men, but did not change with SMMI in women.
conclusionThese results suggest that in ACP, CRF is related to muscle mass and strength, which may provide targets for future interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.